On July 28, 2023 Merus N.V. (Nasdaq: MRUS) (Merus, the Company, we, or our), a clinical-stage oncology company developing innovative, full-length multispecific antibodies (Biclonics and Triclonics), reported that two abstracts were selected for presentation at the European Society for Medical Oncology Congress (ESMO) (Free ESMO Whitepaper) 2023 (Press release, Merus, JUL 28, 2023, View Source [SID1234633485]).
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The presentations will highlight updated interim clinical data for the targeted bispecific antibody, zenocutuzumab (Zeno), with an abstract and oral presentation concerning NRG1 fusion positive (NRG1+) non-small cell lung cancer (NSCLC) and an abstract presentation concerning NRG1+ pancreatic ductal adenocarcinoma (PDAC). The abstracts will be presented at the ESMO (Free ESMO Whitepaper) Congress 2023 taking place in Madrid, Spain October 20-24, 2023.
Merus is currently enrolling patients into the phase 1/2 eNRGy trial to assess the safety and anti-tumor activity of Zeno monotherapy in NRG1+ cancer.
Title: Durable efficacy of zenocutuzumab, a HER2 x HER3 bispecific antibody, in advanced NRG1 fusion-positive (NRG1+) non-small cell lung cancer (NSCLC)
Speaker: Alison Schram
Mini Oral 1315MO
Lecture Time 9:35-9:40 CEST
Saturday, October 21
Title: Durable efficacy of zenocutuzumab, a HER2 x HER3 bispecific antibody, in advanced NRG1 fusion-positive (NRG1+) pancreatic ductal adenocarcinoma (PDAC)
Poster Session 1618P
Sunday, October 22
The full abstracts will be published online via the ESMO (Free ESMO Whitepaper) website at 00:05 CEST on Monday, October 16. They will be available concurrently on the Merus website.
About the eNRGy Clinical Trial
Merus is currently enrolling patients in the phase 1/2 eNRGy trial to assess the safety and anti-tumor activity of Zeno monotherapy in NRG1+ cancer. The eNRGy trial consists of three cohorts: NRG1+ pancreatic cancer; NRG1+ non-small cell lung cancer; and other NRG1+ cancer. Further details, including current trial sites, can be found at www.ClinicalTrials.gov and Merus’ trial website at www.nrg1.com or by calling 1-833-NRG-1234.
About Zeno
Zeno is an antibody-dependent cell-mediated cytotoxicity (ADCC)-enhanced Biclonics that utilizes the Merus Dock & Block mechanism to inhibit the neuregulin/HER3 tumor-signaling pathway in solid tumors with NRG1 fusions (NRG1+ cancer). Through its unique mechanism of binding to HER2 and potently blocking the interaction of HER3 with its ligand NRG1 or NRG1-fusion proteins, Zeno has the potential to be particularly effective against NRG1+ cancer. In preclinical studies, Zeno potently inhibits HER2/HER3 heterodimer formation thereby inhibiting oncogenic signaling pathways, leading to inhibition of tumor cell proliferation, and blocking tumor cell survival.