On June 12, 2023 Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, reported new data demonstrating the ability of the DecisionDx-SCC test to identify cutaneous squamous cell carcinoma (cSCC) tumors at a biologically high risk of metastasis in a subset of patients considered to be at a low risk of metastasis by traditional staging (i.e., patients with T1 tumors under the American Joint Committee on Cancer Eighth Edition (AJCC8) and Brigham and Women’s Hospital (BWH) staging systems) (Press release, Castle Biosciences, JUN 12, 2023, View Source [SID1234632690]). The data was shared in a poster, titled "The 40-gene expression profile (40-GEP) test allows for an improved prognostication of the likelihood of metastasis in patients with T1 cutaneous squamous cell carcinoma (cSCC) with high-risk factors," during the recent 2023 Fall Clinical Dermatology Conference for PAs & NPs.
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"The 40-gene expression profile (40-GEP) test allows for an improved prognostication of the likelihood of metastasis in patients with T1 cutaneous squamous cell carcinoma (cSCC) with high-risk factors"
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"Traditional staging, which includes solely tumor characteristics, only tells part of the story and leaves out a very critical piece of the plot, the biology of an individual patient’s tumor, which can provide greater insight into each patient’s unique metastatic propensity," said Ally-Khan Somani, M.D., Ph.D., board-certified dermatologist, Mohs micrographic surgeon and director of Dermatologic Surgery & Cutaneous Oncology Division at the Indiana University School of Medicine in Indianapolis. "By estimating a cSCC patient’s personal risk of metastasis, the DecisionDx-SCC test has proven to elevate the narrative, which can lead to more informed, pertinent risk-aligned treatment decisions that can help improve outcomes."
In the study, the DecisionDx-SCC test was able to significantly stratify three-year metastasis free survival rates within the AJCC8 and BWH T1 populations of the cSCC cohort. Approximately 70% of the AJCC8- and BWH-staged T1 tumors that metastasized were identified as being biologically high-risk by the DecisionDx-SCC test. This data supports the ability of the test to improve risk assessments based on staging alone, enabling clinicians and patients to make more risk-appropriate surveillance and treatment decisions.
Castle’s poster will be published in SKIN, The Journal of Cutaneous Medicine (www.jofskin.org), and may also be viewed here.
About DecisionDx-SCC
DecisionDx-SCC is a 40-gene expression profile test that uses an individual patient’s tumor biology to predict individual risk of cutaneous squamous cell carcinoma metastasis for patients with one or more risk factors. The test result, in which patients are stratified into a Class 1 (low), Class 2A (moderate) or Class 2B (high) risk category, predicts individual metastatic risk to inform risk-appropriate management.
Peer-reviewed publications have demonstrated that DecisionDx-SCC is an independent predictor of metastatic risk and that integrating DecisionDx-SCC with current prognostic methods can add positive predictive value to clinician decisions regarding staging and management. More information about the disease and test can be found at www.CastleTestInfo.com.