On June 12, 2023 Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM) (Actinium or the Company), a leader in the development of targeted radiotherapies, reported positive SIERRA trial results in an oral presentation at the European Hematology Association (EHA) (Free EHA Whitepaper) 2023 Congress (EHA) (Free EHA Whitepaper) in Frankfurt, Germany on June 10 (Press release, Actinium Pharmaceuticals, JUN 12, 2023, View Source [SID1234632675]). The abstract included data from Actinium’s SIERRA controlled phase 3 study comparing the efficacy of Iomab-B based conditioning, a first-in-class targeted radiotherapy, versus physician’s choice of conventional care in older, relapsed/refractory acute myeloid leukemia (r/r AML) with active disease.
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"We are honored to have been accepted for an oral presentation at EHA (Free EHA Whitepaper)," said Sandesh Seth, Chairman and Chief Executive Officer. "This presentation is the third of four orals at prestigious medical conferences globally in 2023, including TCT, EBMT and SNMMI, reflecting the paradigm changing potential of Iomab-B in facilitating transplants for patients who are currently not considered for transplant."
Details of the EHA (Free EHA Whitepaper) presentation:
Presentation Title: SIERRA trial results with a targeted radiotherapy, Iomab-B, a myeloablative conditioning with reduced intensity tolerability yields high CR, long term survival in HSCT ineligible active r/r AML
Presenting Author: Dr. Boglarka Gyurkocza
Session Type/Title: Oral / SCT Clinical
Presentation ID: S248 (View Source)
Date and Time: June 10, 11:30am – 12:45pm CET
In patients over 55 with active r/r AML, Iomab-B was able to safely deliver myeloablative doses of targeted radiation to bone marrow. Iomab-B based conditioning with bone marrow transplant (BMT) resulted in rapid engraftment and high initial complete remission/complete remission with incomplete platelet recovery rates, a favorable toxicity profile and resulted in statistically significant improvement in the pre-specified primary endpoint of durable complete remission (dCR). The majority of patients who achieved dCR are long term survivors, in whom OS and EFS was significant. Iomab-B based conditioning was well-tolerated and provided access to HSCT with curative potential in a vulnerable patient population traditionally not considered eligible for HSCT.