On June 7, 2023 NanOlogy LLC, a clinical-stage oncology company, reported a presentation of clinical research involving its large surface area microparticle (LSAM) investigational drugs at DDW 2023 in May and publication at ASCO (Free ASCO Whitepaper) Annual Meeting in June (Press release, NanOlogy, JUN 7, 2023, View Source;utm_medium=rss&utm_campaign=nanology-presents-clinical-research-at-2023-ddw-and-asco-involving-its-large-surface-area-microparticle-investigational-drugs [SID1234632562]).
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The DDW poster entitled "Intracystic Injection of Large Surface Area Microparticle Paclitaxel (LSAM-PTX) for Chemoablation of Intraductal Papillary Mucinous Neoplasms: Insights from an Expanded Access Protocol," was presented by the research team of Somashekar Krishna, MD of The Ohio State University Wexner Medical Center. Dr. Krishna, a global expert in the treatment of mucinous pancreatic neoplasms, was a clinical investigator and author of published results (Endosc Int Open 2022) of an earlier clinical trial of intracystic LSAM-PTX in pancreatic cysts. The expanded access protocol prospectively evaluated safety and response of six subjects from the trial who received additional doses of LSAM-PTX. "In this protocol, intracystic LSAM-PTX was safe and resulted in cyst volume and surface area reduction, morphological changes, and loss of pathogenic mutations," said Dr. Krishna. "Further clinical research is warranted particularly in nonsurgical high-risk cyst patients because of the lack of approved treatments to decrease risk for progression to pancreatic cancer."
The ASCO (Free ASCO Whitepaper) abstract (e15187) entitled "Safety of locally administered large surface area microparticle paclitaxel (LSAM-PTX) and docetaxel (LSAM-DTX) in combination with standard of care therapies," was accepted for publication in the ASCO (Free ASCO Whitepaper) annual meeting library. The abstract, authored by Shelagh Verco, PhD, Holly Maulhardt, and other NanOlogy researchers, reviews the safety of both investigational drugs in combination with SOC therapies including various chemotherapies, immune checkpoint inhibitors, and/or radiation across 7 clinical trials totaling 156 patients. The review concluded that local treatment of solid tumors with LSAM-PTX or LSAM-DTX has the potential to overcome some limitations of SOC therapies by increasing tumor dwell time and reducing systemic toxicities which are often exacerbated in combinatorial treatment regimens.