On June 1, 2023 Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) reported an upcoming poster presentation highlighting the Company’s IRAK1/4 program at the 2023 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting being held June 2-6, 2023, in Chicago, IL, and virtually (Press release, Rigel, JUN 1, 2023, View Source [SID1234632355]).
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
Rigel continues to advance the open-label, Phase 1b clinical trial of R2891, an investigational, potent, and selective IRAK1/4 inhibitor, in patients with lower-risk myeloid dysplastic syndrome (LR-MDS) who are refractory/resistant to prior therapies. Rigel has completed enrollment of the first cohort of the trial and enrollment of the second cohort is underway.
Poster Presentation Details:
Abstract #: TPS7085
Title: Phase 1b Clinical Study of IRAK 1/4 Inhibition for Low-Risk Myelodysplastic Syndromes Refractory/Resistant to Prior Therapies
Lead Author: Guillermo Garcia-Manero, M.D., Professor, Chief Section MDS, Deputy Chair Translational Medicine, Leukemia, University of Texas MD Anderson Cancer Center
Session Name: Hematologic Malignancies – Leukemia, Myelodysplastic Syndromes, and Allotransplant
Date: June 5, 2023
Presentation Time: 8:00-11:00 AM CDT
Location: Hall A
The conference abstract can be accessed here.
To learn more about Rigel Pharmaceuticals and the Company’s clinical and commercial hematology/oncology portfolio visit booth #20134 during ASCO (Free ASCO Whitepaper).
About R289
R289 is a prodrug of R8351, an IRAK1/4 dual inhibitor, which has been shown in preclinical studies to block inflammatory cytokine production in response to toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) family signaling. TLRs and IL-1Rs play a critical role in the innate immune response and dysregulation of these pathways can lead to various inflammatory conditions. Chronic stimulation of both these receptor systems is thought to cause the pro-inflammatory environment in the bone marrow responsible for persistent cytopenias in lower-risk MDS patients.