On May 31, 2023 Yuhan Corporation (CEO, Wook-Je Cho) reported that it has signed an in-license agreement with J INTS BIO (CEO, Anna Jo) for a Tyrosine Kinase Inhibitor (TKI) targeting HER2, ‘JIN-A04’ (Press release, YuHan, MAY 31, 2023, View Source [SID1234632310]). The total contract size is 325 million dollars, and it includes an upfront payment of 1.9 million dollars and milestone payments according to future development, permits, and sales.

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JIN-A04 is an oral TKI targeting non-small cell lung cancer carrying HER2 mutations, and there is currently no approved oral drug approved to date. Preclinical data of JIN-A04 was recently presented at the 2023 edition of the American Cancer Research Association (AACR) (Free AACR Whitepaper) annual meeting in April at Orlando, USA showing strong efficacy in both In-vitro and In-vivo studies.

Yuhan Corporation CEO, Wook-Je Cho said, "We have taken a step forward in the development of the 2nd and 3rd LECLAZA by securing an additional anti-cancer drug pipeline with this contract. We plan to further strengthen our anticancer drug pipeline in the future."

Anna Jo, CEO of J INTS BIO, said, "JIN-A04 is expected to be a hope for NSCLC patients with ‘HER2 Exon20 insertion’ mutations." And it can become the most promising Best-in-Class TKI therapy in this field."

Meanwhile, Yuhan invested 1.5 million dollars in J INTS BIO in 2021 and 2022, respectively, and holds a 14.8% stake in the company.