On May 25, 2023 POINT Biopharma Global Inc. (NASDAQ: PNT) (the "Company" or "POINT"), a company accelerating the discovery, development, and global access to life-changing radiopharmaceuticals, reported an upcoming poster presentation for the Company’s ongoing phase 1, pan-cancer, fibroblast activation protein-α (FAP-α)-targeted trial, FRONTIER (NCT05432193), at the 2023 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, taking place June 2-6, 2023, in Chicago, IL (Press release, Point Biopharma, MAY 25, 2023, View Source [SID1234632090]).
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The Trial-in-Progress poster will include trial background information, study design considerations, and a cohort enrollment status update.
Presentation details are as follows:
Title: FRONTIER: FAPi radioligand open-label, phase 1 study to evaluate safety, tolerability and dosimetry of [Lu-177]-PNT6555—A dose escalation study for treatment of patients with select solid tumors
Presenter: Lisa Bodei, MD, PhD, Attending Physician, Director, Targeted Radionuclide Therapy, Molecular Imaging and Therapy Service at Memorial Sloan Kettering Cancer Center
Abstract Number: TPS3161
Session Name: Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Session Date: Saturday, June 3rd
Presentation Time: 8:00 – 11:00 AM CT
Poster Board #: 355a
The associated abstract will be published by ASCO (Free ASCO Whitepaper) on meetings.asco.org at 5:00 PM ET on May 25. The full poster will become available to registered meeting attendees on Saturday, June 3rd at 8:00 AM CT / 9:00 AM ET. The poster will concurrently be archived on POINT’s Investor Relations website View Source
About the FRONTIER Trial
The FAPi Radioligand OpeN-label, phase 1 study to evaluate safety, Tolerability, and dosImetry of [Lu-177]-PNT6555; a dose Escalation study for tReatment of patients with select solid tumors (FRONTIER) trial is an open-label, phase 1 trial to evaluate safety, tolerability, and dosimetry of [Lu-177]-PNT6555 and [Ga-68]-PNT6555, the lead assets of the PNT2004 program. The trial commenced in summer 2022 in Canada and uses a [Ga-68]-based PNT6555 molecular imaging agent to select participants to receive a no-carrier-added (n.c.a.) [Lu-177]-based PNT6555 therapeutic agent. FRONTIER is designed to enroll up to 30 participants across seven FAP-avid cancer indications: colorectal cancer, adenocarcinoma of the pancreas, esophageal cancer, melanoma skin cancer, soft tissue sarcoma, cholangiocarcinoma, and head and neck cancer. Dose level cohorts 1 and 2 have been completed without dose-limiting toxicity. Enrollment to dose level cohort 3 (12 GBq) began in May 2023. We anticipate data from the full FRONTIER study to be available in the first half of 2024.