Abeona Therapeutics Announces Multiple Abstracts Accepted from its AAV Ophthalmology Program at the 26th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT)

On April 10, 2023 Abeona Therapeutics Inc. (Nasdaq: ABEO) reported the acceptance of three abstracts at the 26th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) (Free ASGCT Whitepaper) taking place from May 16-20, 2023 in Los Angeles, CA (Press release, Abeona Therapeutics, APR 10, 2023, View Source [SID1234629898]). Accepted abstracts include new data on three internally developed investigational preclinical gene therapy product candidates from its adeno-associated virus (AAV) ophthalmology program, including ABO-504 for Stargardt disease, ABO-503 for X-linked retinoschisis (XLRS) and ABO-505 for autosomal dominant optic atrophy (ADOA).

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"At ASGCT (Free ASGCT Whitepaper), the data we present will highlight the potential of our proprietary AAV capsids and gene constructs to express recombinant protein in target eye tissues and rescue mutant phenotypes," said Brian Kevany, Ph.D., Chief Technical Officer and Head of Research at Abeona. "We have started to submit pre-IND meeting requests to the FDA for our gene therapy product candidates and anticipate meetings to take place in the second quarter of 2023. We are excited for the opportunity to share our new data with the scientific community at ASGCT (Free ASGCT Whitepaper)."

Details for the poster presentations are as follows:

Abstract Title: In Vivo Production of Full-Length ABCA4 Protein Following Cre-Mediated Recombination from Dual AAV Vectors in ABCA4-/- Mice
Presenter: Dr. Paul Wille, Director, Product Development, Abeona Therapeutics
Session Date/Time: Wednesday, May 17, 2023 at 12:00 PM PT
Abstract number: 715

Abstract Title: ABO-503, a Novel Gene Therapy for Treatment of X-Linked Retinoschisis
Presenter: Dr. Joseph Fogerty, Senior Scientist, Product Development, Abeona Therapeutics
Session Date/Time: Thursday, May 18, 2023 at 12:00 PM PT
Abstract number: 1131

Abstract Title: AAV Gene Therapy for Autosomal Dominant Optic Atrophy Caused by Mutation in the Opa1 Gene
Presenter: Dr. Rachel Stupay, Senior Scientist, Product Development, Abeona Therapeutics
Session Date/Time: Friday, May 19, 2023 at 12:00 PM PT
Abstract number: 1478