On April 4, 2023 Step Pharma, the world leader in CTPS1 inhibition for the targeted treatment of cancer, reported the publication of compelling preclinical data detailing the therapeutic potential of inhibiting CTPS1 in haematological malignancies (Press release, Step Pharma, APR 4, 2023, View Source [SID1234629809]).

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The data, published in HemaSphere (the official journal of the European Hematology Association (EHA) (Free EHA Whitepaper)), describe the identification and characterisation of CTP synthase 1 (CTPS1), an enzyme that catalyses a rate-limiting step in pyrimidine synthesis, as a novel therapeutic target in T cell and B cell malignancies.

Step Pharma’s selective CTPS1 inhibitors induced cell death of neoplastic lymphoid cells in vitro and demonstrated anti-tumour activity in vivo in models of both T cell and B cell malignancies.

STP938, a first-in-class, highly selective, orally bioavailable inhibitor of CTPS1 recently entered a Phase 1/2 trial for T cell and B cell lymphomas (NCT05463263) and study sites are open in the UK and the USA.

Lymphoma is the most common haematological malignancy. Despite improvements in patient survival with modern immunochemotherapy treatments, there remains a significant need for novel targeted agents to treat both T cell and B cell malignancies.