On April 4, 2023 Heidelberg Pharma AG (FSE: HPHA) reported that it will present data from preclinical studies at this year’s American Association for Cancer Research (AACR) (Free AACR Whitepaper) annual meeting that provide positive evidence of the efficacy and tolerability of the company’s proprietary ATAC technology (Press release, Heidelberg Pharma, APR 4, 2023, View Source [SID1234629796]). Heidelberg Pharma is active in cancer research and works with antibody drug conjugates (ADCs) that use the toxin Amanitin as payload. The meeting will be held in Orlando, Florida, USA, from 14th to 19th April 2023.
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
Details of the poster presentation:
Subcutaneous dosing increases the therapeutic index of Amatoxin-based ADCs
Abstract number:
1523, Section 14
Session:
Antibody Drug Conjugates
Date and time:
17th April 2023, 9:00 am – 12:30 pm ET (03:00 – 06:30 pm CEST)
Presenter:
Dr. Kristin Decker
Link to the abstract:
View Source!/10828/presentation/2645
The study investigated how the pharmacokinetics, tolerability and efficacy of different ATACs are affected by the route of administration (subcutaneous versus intravenous). While intravenous dosing is the common administration method for marketed ADCs, subcutaneous dosing in general has pharmacokinetic advantages and is preferable for patients. Subcutaneous (s.c.) dosing of ATACs was shown to result in prolonged half-life and lower maximal serum levels in preclinical models compared with intravenous (i.v.) administration. Both factors resulted in improved tolerability of the ATACs. At the same time, antitumor efficacy in a xenograft model using human cancer cell lines was comparable after s.c. or i.v. administration.
The improved tolerability combined with consistent efficacy resulted in an improved therapeutic index of the candidate HDP-103. The present study demonstrates that s.c. dosing not only refines the pharmacokinetic distribution of ATACs but also can improve the therapeutic index. Thus, s.c. dosing may represent a promising route of administration for ATACs in humans as well.
Details of the poster presentation:
Amanitin-based ADCs targeting Guanylyl cyclase C (GCC) as novel therapeutic modality for treatment of colorectal cancer
Abstract number:
2636, Section 13
Session:
Antibody Technologies
Date and time:
17th April 2023, 1:30 – 5:00 pm ET (07:30 – 11:00 pm CEST)
Presenter:
Alexandra Braun
Link to the abstract:
View Source!/10828/presentation/2173
The poster presentation will cover preclinical data on ATACs targeting GCC (guanylyl cyclase C). This surface protein is overexpressed in many gastrointestinal tumors, and most notably in colorectal cancer. Due to its specific expression profile, GCC represents an exceptionally tumor-specific target. ATACs directed against GCC possess high antitumor activity and inhibit tumor growth in preclinical models even at low concentrations after single or multiple dose treatment. The favorable safety profile due to the good tolerability of these ATACs confirms that they may represent a promising new therapeutic option against colorectal cancer.
Poster presentations can be found from 18th April 2023, on the company website in the "Research & Development > Scientific Posters" section.