On March 29, 2023 Oxford Vacmedix reported completion of Phase 1a in clinical trial of novel cancer vaccine OVM-200 (Press release, Oxford Vacmedix, MAR 29, 2023, View Source;utm_medium=rss&utm_campaign=completion-of-phase-1a-in-clinical-trial-of-ovm-200 [SID1234629501]).
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Oxford Vacmedix (OVM), the UK-based biopharma company focused on the development of vaccines to treat cancer announced today the successful completion of a Phase 1 trial of its lead cancer vaccine; OVM-200 is a cancer vaccine developed using OVM’s novel recombinant overlapping peptide (ROP) platform. It targets survivin, a protein overexpressed by cancer cells that allow unregulated growth, and stimulates an immune response. This trial is both the first time OVM-200 has been used in people and also the first time any ROP based vaccine has been tested in the clinic.
The Phase I trial of OVM-200 is focused on safety and on establishing an immune response in patients with three tumour types – non small cell lung cancer (NSCLC), prostate cancer and ovarian cancer. Patients have been treated at four sites in the UK; University College London Hospital (UCLH), the cancer hospital of the Oxford University Hospitals Foundation Trust (OUHFT), the Christie NHS Foundation Trust in Manchester and the Sarah Cannon Research Institute in London. The Chief Investigator for the trial is Professor Martin Forster, based at UCLH. To date twelve patients have been treated at four dose levels in Phase 1a, the dose escalation part of the trial. A further 24 patients will be treated in Phase 1b.
William Finch, Chief Executive Officer of Oxford Vacmedix, said:
"We are very pleased to have reached this important milestone in the first trial of any vaccine using the ROP technology and also very pleased with the safety and immune response results to date. As the trial is ongoing, we can only share these initial results under confidentiality with potential investors. We are currently in discussion with a number of investors interested in participating in our Series B, to fund the company going forward."
Professor Martin Forster, Chief Investigator based at University College London Hospital added;
"It is a privilege to work with the team at Oxford Vacmedix on this innovative vaccine programme for patients with lung, prostate and ovarian cancer. As clinical investigators we are very excited by the Phase 1a results and look forward to being able to complete this trial of OVM-200. We strongly believe that vaccine treatments will play a major role in future cancer treatments, potentially in combination with immune -oncology agents"