On January 4, 2023 Immunomic Therapeutics, Inc., ("ITI"), a privately-held clinical-stage biotechnology company pioneering the study of LAMP-mediated nucleic acid-based immunotherapy, reported that Dr. William Hearl, Chief Executive Officer, will give a presentation entitled, "Dynamic Activation of the Immune System Using UNITE Technology, Nucleic Acid-Based Cell Therapies for Immuno-Oncology," at Biotech Showcase 2023, being held January 9-11, 2023 in San Francisco (Press release, Immunomic Therapeutics, JAN 4, 2023, View Source [SID1234625807]). Dr. Hearl will discuss ITI’s investigational UNiversal Intracellular Targeted Expression (UNITE) platform and its application in immuno-oncology, specifically glioblastoma multiforme (GBM). ITI’s technology platform has the potential to utilize the body’s natural biochemistry to develop a broad immune response and is currently being employed in a Phase II clinical trial as a cancer immunotherapy.
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Presentation details are as follows:
Who: Dr. William Hearl, Chief Executive Officer of Immunomic Therapeutics, Inc.
What: Dynamic Activation of the Immune System Using UNITE Technology, Nucleic Acid – Based Cell Therapies for Immuno-Oncology
When: Tuesday, January 10, 2023
11:30 AM PST
Track: Franciscan A, Ballroom Level
About UNITE
ITI’s investigational UNITE platform, or UNiversal Intracellular Targeted Expression, works by fusing pathogenic antigens with the Lysosomal Associated Membrane Protein 1 (LAMP1), an endogenous protein in humans, for immune processing. In this way, ITI’s vaccines (DNA or RNA) have the potential to utilize the body’s natural biochemistry to develop a broad immune response including antibody production, cytokine release and critical immunological memory. This approach puts UNITE technology at the crossroads of immunotherapies in a number of illnesses, including cancer, allergy and infectious diseases. UNITE is currently being employed in a Phase II clinical trial as a cancer immunotherapy. ITI is also collaborating with academic centers and biotechnology companies to study the use of UNITE in cancer types of high mortality, including cases where there are limited treatment options like glioblastoma and acute myeloid leukemia. ITI believes that these early clinical studies may provide a proof of concept for UNITE therapy in cancer, and if successful, set the stage for future studies, including combinations in these tumor types and others. Preclinical data is currently being developed to explore whether LAMP1 nucleic acid constructs may amplify and activate the immune response in highly immunogenic tumor types and be used to create immune responses to tumor types that otherwise do not provoke an immune response.