On December 12, 2022, Genprex reported the Safety Review Committee for the Acclaim-1 Phase 1/2 clinical trial that uses a combination of Genprex, Inc.’s REQORSA and AstraZeneca PLC’s Tagrisso in patients with late-stage non-small cell lung cancer that has activating epidermal growth factor receptor (EGFR") mutations and progression after treatment with Tagrisso, approved escalating the dose in the Phase 1 dose escalation portion of the study from 0.09 mg/kg in the second cohort of patients to 0.12 mg/kg in the third and final cohort of patients (Press release, Genprex, DEC 12, 2022, View Source [SID1234625401]).

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