On December 8, 2022 Crown Bioscience, Inc and ERS Genomics Limited (‘ERS’) reported that it has signed a global license agreement for access to the foundational CRISPR/Cas9 patent portfolio held by ERS, which provides the company full license to operate globally using CRISPR/Cas9 for gene editing (Press release, Crown Bioscience, DEC 8, 2022, View Source [SID1234624911]).
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Eric Rhodes, CEO at ERS Genomics
Eric Rhodes, CEO at ERS Genomics
Michael Prosser, Chief Business Officer at Crown Bioscience
Michael Prosser, Chief Business Officer at Crown Bioscience
Crown Bioscience Logo
Crown Bioscience Logo
Crown Bioscience is a global contract research organization (CRO) supporting drug discovery and development for oncology, immuno-oncology, and immune-mediated inflammatory diseases by providing innovative preclinical and translational services to pharmaceutical and biotechnology companies.
ERS holds an exclusive worldwide license from co-founder and 2020 Nobel Prize winner Dr. Emmanuelle Charpentier for the foundational intellectual property covering CRISPR/Cas9 for use as a research platform. ERS Genomics holds over 100 patents worldwide.
The agreement between ERS and Crown Bioscience comes as the industry marks ten years since Charpentier published the study that saw CRISPR-Cas9 repurposed as a gene editing system that paved the way for the suite of technologies now known as CRISPR, transforming the life sciences sector and revolutionizing how scientists work with DNA and RNA.
With this new agreement, Crown Bioscience will expand its gene editing capabilities and investigate the prospect of gene editing in 3D patient-derived tumor organoid models. The agreement also allows the company to develop additional unique and relevant preclinical tools in 3D for higher throughput screens, with the option to add matched in vivo models downstream for translational studies.
"Expanding our current offering provides more innovative drug discovery solutions for our customers," commented Mike Prosser, Chief Business Officer at Crown Bioscience. "We see tremendous potential for using CRISPR gene editing to enhance and manipulate cells and potentially patient derived organoids in both 2D and 3D."
Eric Rhodes, CEO at ERS added: "CRISPR continues to see ever broader use in revolutionizing biotechnology. We are excited to engage with Crown Bioscience and see the technology used in even more cutting-edge applications. Their use of CRISPR to edit cells involved in organoid development is brilliant and we’re always keen to support novel explorations of CRISPR potential."
Financial details of the agreement are not being disclosed.