On November 30, 2022 Promontory Therapeutics Inc., a clinical stage pharmaceutical company advancing small molecule immunotherapies in oncology, will present clinical data on lead therapeutic candidate, PT-112, in combination with avelumab, and its immunogenic cell death inducing effects in patients with advanced non-small cell lung cancer as a poster presentation at the European Society for Medical Oncology Immuno-Oncology (ESMO-IO) Congress 2022 in Geneva, Switzerland, on Dec. 7-9 (Press release, Promontory Therapeutics, NOV 30, 2022, View Source [SID1234624612]).

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Poster Session Details
Title: A phase 2a study of the novel immunogenic cell death (ICD) inducer PT-112 plus avelumab ("PAVE") in advanced non-small cell lung cancer (NSCLC) patients (pts)
Presentation Number: 125P
Session location: Foyer ABC, Palexpo Exhibition Centre
Session time: Thursday, December 8, 2022, 12:30 p.m. to 1:15 p.m. CET
Speaker/Lead Author: Martina Imbimbo, MD, Lausanne University Hospital, Switzerland

Abstracts will be published online on the ESMO (Free ESMO Whitepaper) website at 12:05 a.m. CET on Thursday, Dec. 1, 2022. Abstracts will also be published online in the ESMO (Free ESMO Whitepaper)-IO Congress 2022 Abstract Book, a supplement to the official ESMO (Free ESMO Whitepaper) journal, Immuno-Oncology and Technology (IOTECH).

For more information about PT-112 and Promontory Therapeutics’ clinical pipeline visit www.PromontoryTx.com.

About PT-112

PT-112 is the first small-molecule conjugate of pyrophosphate in oncology, and possesses a unique pleiotropic mechanism of action that promotes immunogenic cell death (ICD), through the release of damage associated molecular patterns (DAMPs) that bind to dendritic cells and lead to downstream immune effector cell recruitment in the tumor microenvironment. PT-112 represents a highly potent inducer of this immunological form of cancer cell death. Further, PT-112 harbors a property known as osteotropism, or the propensity of the drug to reach its highest concentrations in certain areas of the bone, making it a candidate for treatment of patients with cancers that originate in, or metastasize to, the bone. The first in-human study of PT-112 demonstrated an attractive safety profile and evidence of long-lasting responses among heavily pre-treated patients and won "Best Poster" within the Developmental Therapeutics category at the ESMO (Free ESMO Whitepaper) 2018 Annual Congress. The combination Phase 1b dose escalation study of PT-112 with PD-L1 checkpoint inhibitor avelumab in solid tumors was reported in an oral presentation at the ESMO (Free ESMO Whitepaper) 2020 Virtual Congress and the Phase 2a dose confirmation cohort in non-small cell lung cancer (NSCLC) patients will be reported at ESMO (Free ESMO Whitepaper) IO 2022. The Phase 1 study in patients with relapsed or refractory multiple myeloma presented at ASH (Free ASH Whitepaper) is the third completed Phase 1 study of PT-112. Monotherapy Phase 2 development is ongoing in mCRPC, and now includes the Phase 2 proof of concept study in thymic epithelial tumors under the company’s formal collaboration with the NCI.