On August 30, 2022 MAIA Biotechnology, Inc., (NYSE American: MAIA) ("MAIA"), a targeted therapy, immuno-oncology company focused on developing potential first-in-class oncology drugs, reported that it has been selected to conduct an oral presentation covering the novel THIO platform at the XIV International Round Table on Nucleosides, Nucleotides, and Nucleic Acids, which will be taking place in Stockholm, Sweden on August 28 – 31, 2022 (Press release, MAIA Biotechnology, AUG 30, 2022, View Source [SID1234618788]).
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This scientific exchange presentation will summarize an unexpected, yet promising, property of MAIA’s THIO platform, a modified nucleoside – 6-thio-2’-deoxyguanosine (6-thio-dG;), as a potential anticancer agent. It will demonstrate the importance of cancer cell telomeric DNA structural and functional integrity, as well as therapeutically attractive opportunity to induce stress, increase innate sensing and adaptive antitumor immunity via "cancer cell self-produced" chemical modification of telomeres.
"Since their discovery, telomeres and telomerase of cancer cells have drawn significant scientific interest as attractive targets as potentially selective anti-tumor therapies. We are thrilled to have been given the opportunity to present our findings regarding the novel THIO platform as a modified nucleoside, telomerase substrate precursor, and potential anticancer agent," said Sergei Gryaznov, Ph.D., Chief Scientific Officer of MAIA. "We have demonstrated that the compound is a potentially potent and specific anticancer agent that also activates both innate and adoptive immune systems through induction of cGAS/STING pathway. Intriguingly, administration of THIO has shown the potential to overcome resistance to immune checkpoint blockade, by anti-PD-1 or anti-PD-L1 agents, in advanced in vivo syngeneic cancer models, leading to profound anticancer effects, and to induction of tumor type specific long-term anticancer memory in mice."
"We are delighted to have been selected to present our data at the XIV International Round Table," said Vlad Vitoc, M.D., MAIA’s Chairman and Chief Executive Officer. "This reflects the scientific community’s interest in our unique approach to treatment of cancer."
Presentation Title: "Telomerase-Driven Telomeric DNA Modification in Cancer Cells Leads to Efficient Induction of cGAS-mediated Innate and Adoptive Immune Responses"
Lead Authors: Sergei M. Gryaznov, MAIA Biotechnology, Inc., Chicago, IL and Jerry W. Shay, University of Texas, Southwestern Medical Center, Dallas, TX
Dates: Sunday, August 28, 2022 to Wednesday, August 31, 2022
Location: Karolinska Institutet Campus Solna, in the building Aula Medica. Nobels väg 6, Solna
For more information about the oral presentation, please visit www.maiabiotech.com/publications/.
About THIO
THIO (6-thio-dG or 6-thio-2’-deoxyguanosine) is a telomere-targeting agent currently in clinical development to evaluate its activity in non-small cell lung cancer (NSCLC), in sequential administration with cemiplimab, a PD-1 inhibitor developed by Regeneron. Telomeres play a fundamental role in the survival of cancer cells and their resistance to current therapies. THIO is being developed as a second or later line of treatment for NSCLC for patients that have progressed beyond the standard-of-care regimen of existing checkpoint inhibitors.