On August 3, 2022 Merrimack Pharmaceuticals, Inc. (Nasdaq: MACK) [("Merrimack" or the "Company")] reported that Ipsen, SA ("Ipsen") has issued its primary analysis of the results of its Phase 3 trial of Onivyde (irinotecan liposomal injection) as a treatment of second line small cell lung cancer (SCLC) (Press release, Merrimack, AUG 3, 2022, View Source [SID1234617382]). The press release indicates that the "the primary endpoint OS was not met in patients treated with Onivyde versus topotecan. However, a doubling of the secondary endpoint of objective response rate (ORR) in favor of Onivyde was observed. The safety and tolerability of Onivyde was consistent with its already-known safety profile, and no new safety concerns emerged. The clinical study results will be communicated with the regulatory agency." Ipsen indicated in its update that it will analyze the data further before making decisions about next steps.

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"We will continue to monitor updates from Ipsen regarding the SCLC program," said Gary Crocker, Chairman and CEO of Merrimack Pharmaceuticals. "Ipsen also reported in its recent H1 2022 financial results update provided on July 29, 2022, that it expects to publicly report its top line data from its continuing Phase 3 study of Onivyde in first line pancreatic ductal adenocarcinoma before the end of 2022.