On August 2, 2022 PharmaJet, a biotech company that, with their innovative needle-free technology, has developed a more effective way of administering drugs and biologics to accelerate research, commercialization and public health outcomes, reported that its partner, Scancell, will include needle-free delivery of their Phase 2 clinical study for treatment of patients with advanced melanoma (Press release, Scancell, AUG 2, 2022, View Source [SID1234617307]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Skin cancer is by far the most common of all cancers. Melanoma accounts for only about 1% of skin cancers but causes a large majority of skin cancer deaths. The American Cancer Society’s estimates about 100,000 new melanomas will be diagnosed in the United States in 2022 and nearly 8% of those diagnosed are expected to die from it.1

Scancell’s immunotherapy platform uses the body’s immune system to identify, attack and destroy tumors. In the Phase 1/2 clinical trial, 89% of the resected patients survived for more than 5 years following vaccination with their SCIB1 vaccine. The Phase 2 study is designed to assess whether the addition of SCIB1 treatment to pembrolizumab or ipilimumab/nivolumab results in an improvement in patient outcomes for patients with metastatic disease. The updated protocol adds needle-free injection with the PharmaJet Stratis System as Scancell believes needle-free delivery could improve patient acceptance. Scancell is also using one of PharmaJet’s WHO-prequalified Needle-free Injection Systems for delivery of two SARS-CoV-2 DNA vaccine candidates, currently being evaluated in South Africa.

Chris Cappello, President and CEO, PharmaJet, commented, "We are pleased to be partnering with Scancell as they start their Phase 2 trial with a needle-free delivery option for patients with advanced melanoma. In addition to increasing patient acceptance, our partners have published data showing superior results to electroporation, and improved immunogenicity with DNA vaccines."