On July 25, 2022 Athenex, Inc., (NASDAQ: ATNX), a global biopharmaceutical company dedicated to the discovery, development, and commercialization of novel therapies for the treatment of cancer and related conditions, reported the publication of their manuscript, "Open-Label, Randomized, Multicenter, Phase III Study Comparing Oral Paclitaxel Plus Encequidar Versus Intravenous Paclitaxel in Patients with Metastatic Breast Cancer" (Press release, Athenex, JUL 25, 2022, View Source [SID1234616894]). The article, along with results, can be found on the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Journal’s website at this link.
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"We are pleased with the publication of the phase 3 data, which show that oral paclitaxel plus encequidar significantly improves tumor response in patients with metastatic breast cancer, compared to IV administration. Positive trends were observed in progression free survival and overall survival," said Hope S. Rugo, MD, Professor of Medicine, University of California San Francisco Comprehensive Cancer Center. "With oral administration of paclitaxel plus encequidar, we observed less frequent and less severe neuropathy, which is often a limiting toxicity with IV taxanes. In patients with abnormal liver function, we identified a predisposition to early neutropenia and infections in patents with elevated liver enzymes at baseline, allowing for better toxicity management moving forward. We believe that for appropriate patients with advanced or metastatic breast cancer, this could potentially be an effective at home treatment option."