On June 30, 2022 Umoja Biopharma, Inc., an immuno-oncology company pioneering off-the-shelf, integrated therapeutics that reprogram immune cells in vivo to treat patients with solid and hematologic malignancies, reported that the company will participate in two Hanson Wade summits taking place in July in Boston (Press release, Umoja Biopharma, JUN 30, 2022, View Source [SID1234616411]). Details can be found below.

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In Vivo Engineering of Therapeutic Cells Summit held July 12-14, 2022

Umoja’s participation will begin on July 13:

Participation: Panel
Title: Applying In Vivo CAR-T Cell Therapy for Oncology and Beyond
Umoja Speaker: Shon Green, Ph.D., Senior Director, Translational R&D (In-Vivo)
Details: The panel will address how in vivo CAR T-cell therapy obviates current ex vivo bottlenecks including access, efficacy, and toxicity as well as achieving transient versus longer-term effects for different indications.
Time: 12:30 PM ET

Participation: Poster
Title: Preclinical development of UB-VV100, a novel platform for in vivo engineering of therapeutic anti-CD19 CAR T cells
Umoja Speaker: Susana Hernandez Lopez, Scientist
Time: 3:00 PM ET

Umoja’s participation will continue July 14:

Participation: Fireside Chat
Title: In Vivo Engineering of Therapeutic Cells as the Future of Cell and Gene Therapy
Umoja Speaker: Andy Scharenberg, M.D., Co-founder and CEO
Details: The fireside chat will evaluate what has inspired the industry to move from ex vivo to in vivo therapies, outline the advantages and opportunities that in vivo cell and gene therapies offer over current generations, and discuss the next steps to streamline pre-clinical development to fast-track in vivo therapies to the clinic.
Time: 9:15 AM ET

Participation: Oral Presentation
Title: In Vivo Approaches to Generate CAR T Cells Engineered to Mediate Durable Antitumor Responses
Umoja Speaker: Ryan Larson, Ph.D., Vice President, Head of Immunology
Details: The presentation will cover how manufacturing complexities limit patient access to autologous CAR T-cell products, the ability of Umoja’s VivoVec off-the-shelf lentiviral vector platform to enable efficient generation of functional CAR T-cells in vivo, and how the approach can be applied to target both hematological and solid tumor cancers.
Time: 11:30 AM ET

iPSC Manufacturing Summit from July 26-28, 2022

Umoja’s participation will begin on July 28:

Participation: Oral Presentation
Title: Engineering iPSCs with Synthetic Receptors to Drive Differentiation Compatible with Scale-Up
Umoja Speaker: Teisha Rowland, Ph.D., Principal Scientist, iPSC Team Lead
Details: The presentation will cover how iPSCs can more efficiently be differentiated into functional, persistent immune cell types by genetically engineering iPSCs to express a synthetic cytokine receptor, how differentiation can be performed in suspension to make it compatible with efficient scale-up production, and how the overall approach may be used in a manufacturing setting to drive high-purity immune cell production.
Time: 11:45 AM ET