On June 6, 2022 TwinStrand Biosciences, Inc., the pioneer in duplex sequencing technology, reported that the company will present several data sets as part of its sponsorship and participation in the annual Advances in Genome Biology and Technology conference in Orlando on June 6-9, 2022 (Press release, TwinStrand Biosciences, JUN 6, 2022, View Source [SID1234615650]). The studies will highlight advances in TwinStrand’s innovative technology and share recent research that demonstrates the power of duplex sequencing for some of the most demanding applications in clinical and foundational research.

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"At TwinStrand, we continue to make progress and see the impact of our technology in important areas like hematology-oncology, genetic toxicology, and cellular therapies," said Jesse Salk, M.D., Ph.D., TwinStrand’s Cofounder, and CEO. "We are pleased to share this progress with the AGBT community and look forward to forming new collaborations that leverage our highly sensitive and specific Duplex Sequencing technology which has consistently demonstrated its potential as a critical decision support tool in medicine, public health, and other fields of science where high-resolution insights are most impactful."

TwinStrand DuplexSeq AML-29 Minimal Residual Disease (MRD) Assays offer high-sensitivity detection of ultra-low frequency mutations in acute myeloid leukemia (AML) cases. The 29-gene panel covers loci that are mutated in up to 95% of adult AML patients and is several orders of magnitude more sensitive and specific than other next-generation sequencing-based (NGS) MRD assays. TwinStrand is a member of the Foundation for the National Institutes of Health Biomarkers Consortium, which recently launched a program to validate and standardize methods of detecting and quantifying MRD in AML patients.

TwinStrand DuplexSeq Mutagenesis Assays offer a novel NGS-based approach to mutational research that detects, quantifies, and characterizes genome mutagenesis. It is the first NGS technology able to directly measure ultra-rare mutations caused by chemical carcinogens, without requiring biological selection and is applicable in vitro and in vivo. The final output is comprehensive data on induced mutations including frequency, simple spectrum, and trinucleotide signatures. TwinStrand is collaborating with the Health and Environmental Sciences Institute (HESI), the UK branch of the European Environmental Mutagenesis Society (UKEMS), and the US National Institutes of Standards (NIST) to showcase the value of error-corrected NGS for various preclinical research and regulatory applications.

AGBT attendees can learn more about TwinStrand technology in the Escambia suite. The company will share details from its pioneering work and partnerships in the field of genetic toxicology, which has significant implications for future regulatory mutagenicity and carcinogenicity testing. Other data sets will showcase recent applications of TwinStrand DuplexSeq products in acute myeloid leukemia and allogeneic cell therapy, including:

Ultra-Sensitive Duplex Sequencing for Quantifying Multi-Individual Cell Therapy Sub-Population Fractions
Authors from TwinStrand Biosciences and Deverra Therapeutics
Duplex Sequencing for Ultra-Low Frequency Measurable Residual Disease Detection in Adult Acute Myeloid Leukemia
Authors from TwinStrand Biosciences, Fred Hutchinson Cancer Research Center, National Heart, Lung, and Blood Institute – National Institutes of Health, and Children’s Hospital Los Angeles
Duplex Sequencing Reveals Ubiquitous Clonal Hematopoiesis and Complex Donor-Recipient Clonal Dynamics Following Hematopoietic Stem Cell Transplant
Authors from TwinStrand Biosciences and Fred Hutchinson Cancer Research Center
Longitudinal Monitoring of Pediatric Acute Myeloid Leukemia Using Duplex Sequencing of Patient-Specific Panels Reveals Ultra-Low Frequency MRD that Marks Persistent Carcinogenesis and Complex Clonal Evolution
Authors from TwinStrand Biosciences, Fred Hutchinson Cancer Research Center, and University of California San Francisco