On May 26, 2022 Alpine Immune Sciences, Inc. (NASDAQ: ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for cancer and autoimmune and inflammatory diseases, reported the acceptance of abstracts for presentation at the 2022 European Congress of Rheumatology (EULAR) Annual Congress in Copenhagen, Denmark to be held June 1–4, 2022 and the 2022 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting in Chicago to be held June 3-7, 2022 (Press release, Alpine Immune Sciences, MAY 26, 2022, View Source [SID1234615067]).
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EULAR Annual Congress
Novel preclinical and preliminary phase 1 healthy volunteer data of ALPN-303 will be presented as follows:
ASCO Annual Meeting
Updated data from the dose escalation portion of NEON-1, a phase 1 study of davoceticept as monotherapy, and a trials in progress poster of NEON-2, a phase 1 combination study of davoceticept and pembrolizumab, will be presented at poster presentations as follows:
About ALPN-303
ALPN-303 is a dual B cell cytokine antagonist being developed for multiple autoimmune and/or inflammatory diseases. Engineered by directed evolution, ALPN-303 potently inhibits the pleiotropic B cell cytokines B cell activating factor (BAFF, BLyS) and a proliferation inducing ligand (APRIL), which play key roles in B cell development, differentiation, and survival, and together contribute to the pathogenesis of multiple autoimmune diseases like systemic lupus erythematosus (SLE) and many other autoantibody-related inflammatory diseases. By simultaneously blocking these two cytokines, ALPN-303 has the potential to improve outcomes in patients suffering from severe autoimmune and/or inflammatory diseases.
About Davoceticept (ALPN-202)
Davoceticept (ALPN-202) is a first-in-class, conditional CD28 costimulator and dual checkpoint inhibitor intended for the treatment of cancer. Preclinical studies of davoceticept have successfully demonstrated superior efficacy in tumor models compared to checkpoint inhibition alone. NEON-1 (NCT04186637), a Phase 1 monotherapy dose escalation and expansion trial in patients with advanced malignancies, has completed dose escalation and is currently enrolling its expansion cohorts. NEON-2 (NCT04920383), a combination study of davoceticept (ALPN-202) and pembrolizumab, was initiated in June 2021.