On April 8, 2022 Repare Therapeutics Inc. ("Repare" or the "Company") (Nasdaq: RPTX), a leading clinical-stage precision oncology company, reported it has been selected for an oral presentation of clinical data from its ongoing Phase 1/2 TRESR (Treatment Enabled by SNIPRx) trial of RP-3500, a potent and selective oral small molecule inhibitor of ATR (Ataxia-Telangiectasia and Rad3-related protein kinase), as well as two additional poster presentations at the upcoming 2022 AACR (Free AACR Whitepaper) Annual Meeting held in New Orleans on April 8-13, 2022 (Press release, Repare Therapeutics, APR 8, 2022, View Source [SID1234611754]).
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The Company also announced that it will host a conference call with accompanying slides for analysts and investors on Monday, April 11, 2022 at 6:30 p.m. Eastern Time. The call and presentation will include RP-3500 data presented at the 2022 AACR (Free AACR Whitepaper) Annual Meeting as well as additional data, representing an update from data in the Company’s abstract (referenced below), which reflects an earlier cut-off date.
"As with any new therapeutic class, differentiation among early product candidates is what ultimately determines success in the clinic and a path toward registration," commented Lloyd M. Segal, President and Chief Executive Officer of Repare. "In the context of data published as recently as today, we are confident that RP-3500 is a highly differentiated and potentially leading ATR inhibitor. We continue to draw on a wealth of data from the comprehensive Phase 1 monotherapy module of our Phase 1/2 TRESR trial of RP-3500 to begin establishing its therapeutic potential. We look forward to seeing these data presented at AACR (Free AACR Whitepaper) and discussing RP-3500’s ongoing and future development plans."
Oral Presentation Details on RP-3500 Phase 1/2 TRESR Trial Results:
Title: Genomic and pathologic determinants of response to RP-3500, an ataxia telangiectasia and Rad3-related inhibitor (ATRi), in patients (pts) with DNA damage repair (DDR) loss-of-function (LOF) mutant tumors in the Phase 1/2 TRESR trial
Presenter: Dr. Timothy Yap, MBBS, Ph.D., FRCP, Medical Director, Institute for Applied Cancer Science, Associate Professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, MD Anderson Cancer Center, Houston, Texas
Abstract Number: CT030
Session Title: Clinical Trials Minisymposium – Patient Selection Strategies for Molecularly Targeted Agents in Clinical Trials
Date/ Time: Monday, Apr 11, 2022 at 3:05 PM – 3:15 PM CT
Poster Presentation Details on SNiPDx Panel for Synthetic Lethal Drug Discovery:
Title: Detection of biallelic loss of DNA repair genes in formalin-fixed, paraffin embedded (FFPE) tumor samples using a novel tumor-only sequencing panel with error correction
Presenter: Dominik Glodzik, Ph.D., Repare Therapeutics, Instructor in Biomedical Informatics, Harvard Medical School
Abstract Number: 2801
Session Title: Diagnostic Biomarkers
Date/ Time: Tuesday, April 12, 2022 at 9:00 AM CT
Poster Details on Preclinical Data for PKMYT1 Inhibitor RP-6306:
Title: RP-6306, a novel PKMYT1 inhibitor, demonstrates synthetic lethality as monotherapy and in combination with gemcitabine in CCNE1 amplified cancer cells
Presenter: Jimmy Fourtounis, Repare Therapeutics
Abstract Number: 5650
Session Title: Cell Cycle
Date/ Time: Friday, April 8, 2022 at 12:00 – 1:00 PM CT
Company Conference Call:
The Company will host a conference call with accompanying slides for analysts and investors on Monday, April 11, 2022 at 6:30 p.m. Eastern Time to further discuss the RP-3500 data presented at the 2022 AACR (Free AACR Whitepaper) Annual Meeting. Repare’s executive management team will be joined by Timothy Yap, MBBS, PhD, FRCP, Principal Investigator and Medical Director, Institute for Applied Cancer Science, Associate Professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, MD Anderson Cancer Center, Houston, TX.
To access the call, please dial (877) 870-4263 (U.S. and Canada) or (412) 317-0790 (international) at least 10 minutes prior to the start time and ask to be joined to the Repare Therapeutics call. A live video webcast will be available in the Investor section of the Company’s website at View Source A webcast replay will also be archived for at least 30 days.
About Repare Therapeutics’ SNIPRx Platform
Repare’s SNIPRx platform is a genome-wide CRISPR-based screening approach that utilizes proprietary isogenic cell lines to identify novel and known synthetic lethal gene pairs and the corresponding patients who are most likely to benefit from the Company’s therapies based on the genetic profile of their tumors. Repare’s platform enables the development of precision therapeutics in patients whose tumors contain one or more genomic alterations identified by SNIPRx screening, in order to selectively target those tumors in patients most likely to achieve clinical benefit from resulting product candidates.