On April 6, 2022 Anixa Biosciences, Inc. (NASDAQ: ANIX), a biotechnology company focused on the treatment and prevention of cancer and infectious diseases, reported that the inventor of its ovarian cancer CAR-T technology, Dr. José Conejo-Garcia, Chair of the Immunology Department at Moffitt Cancer Center, will be presenting at The 4th International Workshop on CAR-T (iwCAR-T) 2022 on Friday, April 29, 2022 (Press release, Anixa Biosciences, APR 6, 2022, View Source [SID1234611517]). Dr. Conejo-Garcia will be chairing a panel on breast and ovarian cancers and will discuss the use of Chimeric Endocrine Receptor T-cell (CER-T) technology for treating ovarian cancer, an approach he invented that is in development with Anixa. A Phase 1 clinical trial of the therapy based on this technology was recently activated at Moffitt Cancer Center.
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During the presentation, titled, "Chimeric Endocrine Receptor (CER) T-cell technology for ovarian cancer," Dr. Conejo-Garcia will discuss the technology, which is an autologous cell therapy comprised of engineered T-cells that target the follicle stimulating hormone receptor (FSHR). FSHR is found at immunologically relevant levels exclusively on the granulosa cells of the ovaries. Since the target is a hormone receptor, and the target-binding domain is derived from its natural ligand, this technology is also known as CER-T (Chimeric Endocrine Receptor T-cell) therapy, a new type of CAR-T.
"I am excited to discuss our novel FSHR-mediated CAR-T technology at this event as part of the goal to share knowledge and research in CAR-T and immunotherapies," stated Dr. Conejo-Garcia. "Moffitt has been working in collaboration with Anixa to advance this program into human clinical studies, and we are thrilled to have recently activated the trial. We look forward to verifying results of this therapeutic approach in solid tumors. Importantly, if this therapeutic approach is successful this could enable a significant shift in the overall treatment paradigm for ovarian cancer."
Dr. José Conejo-Garcia and his research team developed the FSHR-mediated CAR-T technology when he was at the Wistar Institute where he contributed to report for the first time on the role of T-cell responses in the outcome of ovarian cancer patients. Anixa has an exclusive, world-wide license to this technology.
More information about the event can be found at: iwCAR-T.