On January 20, 2022 TriSalus Life Sciences, an immunotherapy company on a mission to extend and improve the lives of patients living with liver and pancreatic tumors, reported a strategic research collaboration with the University of Colorado Anschutz Medical Campus to advance research of immuno-oncology treatments for patients with liver and pancreatic tumors (Press release, TriSalus Life Sciences, JAN 19, 2022, View Source [SID1234605649]). This collaboration will leverage TriSalus’ immunotherapy platform, which integrates immunotherapeutics and innovative drug delivery technology to address the unique challenges of treating tumors in the liver and pancreas and improve outcomes for patients.
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Over the next three years, TriSalus will collaborate with the University of Colorado Anschutz Medical Campus on studies using TriSalus’ proprietary Pressure-Enabled Drug Delivery (PEDD) method for the administration of an investigational toll-like receptor 9 (TLR9) agonist, SD-101. Pre-clinical and clinical studies involving this platform aim to build upon the scientific knowledge around treatments available for cancers of the liver and pancreas and enable more patients to benefit from immunotherapy. In collaborating with TriSalus, CU Innovations has led the establishment of the business relationship while the CU Anschutz research team will focus on creating clinical research to advance TriSalus’ approach.
"This collaboration bolsters the instructional and research objectives of the University of Colorado Anschutz Medical Campus while fostering the development of scientific knowledge that can improve patient care," said Gordon McLennan, MD, vice chairman for clinical research and section chief of interventional radiology at the University of Colorado School of Medicine. "As a world-class medical institution at the forefront of transformative science, education and healthcare, we look forward to collaborating with TriSalus Life Sciences to help bring potentially transformative treatments to patients living with liver and pancreatic cancers."
Despite progress in cancer treatment, patients with liver and pancreatic tumors still experience poor outcomes, as these tumors remain stubbornly difficult to treat. Two of the most significant barriers that prevent optimal delivery and performance of therapeutics for these tumors include immune response suppression and ineffective drug delivery due to high intratumoral pressure. Together, these barriers prevent therapeutics from getting inside tumors and limit the effectiveness of immunotherapy for patients.
"Supporting pre-clinical and clinical research that pushes the boundaries of current knowledge will help us to advance promising therapies for patients with liver and pancreatic tumors, who are in desperate need of more effective treatments," said Christopher Lieu, MD, associate director of clinical research at the University of Colorado Cancer Center.
TriSalus’ platform consists of an investigational immunotherapy, SD-101, that aims to reactivate the immune system within these organs for targeted tumor killing, and the Pressure-Enabled Drug Delivery method, that modulates pressure and flow within blood vessels to improve therapy uptake and tumor response.
"Collaborating with the University of Colorado Anschutz Medical Campus exemplifies our commitment to overcome current limitations of immunotherapy treatment for liver and pancreatic tumors," said Steven C. Katz, MD, FACS, chief medical officer at TriSalus. "By combining our collective expertise in cancer research, together we can help realize the potential for the TriSalus platform to bring meaningful benefit to patients."
The collaboration with University of Colorado Anschutz Medical Campus extends TriSalus’ ongoing partnerships with the country’s leading cancer centers. To learn more about clinical trials underway, visit trisaluslifesci.com.