On January 6, 2022 Biohaven Pharmaceutical Holding Company Ltd. (NYSE: BHVN), a biopharmaceutical company with a portfolio of innovative, late-stage product candidates, reported preliminary net product revenue of NURTEC ODT (rimegepant) for the fourth quarter of 2021 (Press release, Biohaven Pharmaceutical, JAN 6, 2022, View Source [SID1234598503]).

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Based on preliminary unaudited financial information, the Company reported approximately $190 million in net product revenue from sales of NURTEC ODT in the fourth quarter of 2021 and approximately $462 million in net product revenue for 2021. There were no material changes in channel inventory days over the course of the year.

The foregoing information reflects the Company’s estimate with respect to net product revenue for NURTEC ODT based on currently available information, which is preliminary and unaudited, is not a comprehensive statement of the Company’s financial results and is subject to completion of the Company’s financial closing procedures. The Company’s final results, which will be issued upon completion of its closing procedures, may vary from these preliminary estimates.

Vlad Coric, M.D., Chairman and Chief Executive Officer of Biohaven commented, "NURTEC ODT has changed the treatment paradigm for migraine with its dual-acting, acute and preventive indications. NURTEC ODT established itself as the market leading novel migraine therapy in 2021 and generated an impressive $462 million in net product revenue for the year. The dual indications offer healthcare providers and their patients a single treatment they can customize to treat and prevent migraine attacks. We remain steadfast in our commitment to the migraine community to support programs that drive awareness of migraine and the importance of effective treatment to reduce disability."

Approximately 40 million people in the U.S. and more than one billion individuals worldwide suffer from migraine. Migraine is the third most prevalent illness in the world and the World Health Organization classifies migraine as one of the 10 most disabling medical illnesses.

BJ Jones, Chief Commercial Officer, Migraine & Common Disease, added, "Every day we hear from patients and healthcare providers about the benefits of using NURTEC ODT to help stop a migraine attack quickly and prevent the next one. The overwhelming number of patients that share the positive impact that NURTEC ODT has for them
continues to inspire our team to do more to help those suffering from migraine. Our team is dedicated to continuing to deliver NURTEC ODT to as many patients as possible, especially during times of stress in the pandemic."
NURTEC ODT 75 mg is the only migraine medication approved as a dual therapy for both acute and preventive treatment, and is the first oral CGRP receptor antagonist approved for the preventive treatment of migraine. NURTEC ODT targets a key driver of migraine by reversibly blocking CGRP receptors, thereby inhibiting the biologic cascade that results in a migraine attack. A single dose of NURTEC ODT can deliver fast pain relief with some patients returning to normal function by 60 minutes and has a lasting effect of up to 48 hours for many patients. NURTEC ODT can be taken up to once daily, up to 18 doses/month, as needed to stop migraine attacks or taken every other day to help prevent migraine attacks and reduce the number of monthly migraine days. NURTEC ODT does not have addiction potential and is not associated with medication overuse headache or rebound headache.

NURTEC ODT was approved by the U.S. Food and Drug Administration (FDA) for the acute treatment of migraine in February 2020 and for the preventive treatment of episodic migraine in May 2021 with commercial launch commencing within weeks of the approvals.