On September 30, 2021 Tango Therapeutics, Inc. (NASDAQ: TNGX), a biotechnology company committed to discovering and delivering the next generation of precision cancer medicines, reported that five abstracts have been selected for presentation as virtual posters at the AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper) on October 7 – 10, 2021 (Press release, Tango Therapeutics, SEP 30, 2021, View Source [SID1234590595]).
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"The preclinical data being presented today highlight the potential applicability of synthetic lethal drug targeting across a range of cancer types. As an example, our lead program, TNG908, an MTA-cooperative PRMT5 inhibitor selective for cancers with deletion of the MTAP gene, shows strong regressions across multiple types of cancer," said Barbara Weber, M.D., president and Chief Executive Officer of Tango Therapeutics. "We look forward to leveraging these data to inform our planned clinical development program."
Dr. Weber will also be co-chairing an Educational session titled "Exploiting Synthetic Lethality" on October 7, 2021 at 10:00 AM ET.
Details on Tango’s presentations at AACR (Free AACR Whitepaper)-NCI-EORTC are as follows:
Poster Title: MTAPnull-selective PRMT5 inhibitors drive regressions in MTAP-deleted xenograft models across histologies
Abstract #: P214
Date and Time: October 7, 9:00 AM ET
Poster Title: VRK1 is a novel synthetic lethal target in VRK2-methylated glioblastoma
Abstract #: P182
Date and Time: October 7, 9:00 AM ET
Poster Title: CRISPR screens identify sensitizers to Trametinib in KRAS mutant cancer cell lines
Abstract #: P183
Date and Time: October 7, 9:00 AM ET
Poster Title: Loss of HS2ST1 cooperates with MAPK inhibition to impair growth of mesenchymal KRAS mutant NSCLC
Abstract #: P146
Date and Time: October 7, 9:00 AM ET
Poster Title: Isogenic CRISPR Anchor Screens identified actionable nodes to CHK1/2 inhibitor Prexasertib in TP53 mutant cancer
Abstract #: P095
Date and Time: October 7, 9:00 AM ET