On July 26, 2021 Harbour BioMed ("HBM", HKEX: 02142) reported that the abstract detailing clinical data from its Australian phase I study of next-generation anti-CTLA-4 antibody in patients with advanced solid tumors will be presented as an e-poster at the 2021 European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress, which is expected to be held 16-21 September 2021 (Press release, Harbour BioMed, JUL 26, 2021, View Source [SID1234585203]).
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As the first fully human heavy chain only antibody (HCAb) under the clinical investigation, HBM4003 is generated from Harbour Mice platform. This Study is an open-label, dose-escalating monotherapy study in treatment of advanced solid tumors. The preliminary clinical data demonstrate encouraging anti-tumor efficacy of HBM4003 with the good safety profile and tolerability. The data obtained from the Study have further validated pre-clinical findings of HBM4003’s unique PK/PD profile, novel mechanism of action and low immunogenicity. The Company has proceeded with multiple global phase Ib/IIa trials in solid tumors in light of the encouraging clinical efficacy and safety profile.
About HBM4003
HBM4003 is the fully human anti-CTLA-4 monoclonal heavy chain only antibody (HCAb) generated from Harbour Mice. By enhancing antibody-dependent cell cytotoxicity (ADCC) killing activity, HBM 4003 has demonstrated significantly improved depletion specific to high CTLA-4 Treg cells in tumor tissues. The potent anti-tumor efficacy and differentiated pharmacokinetics with durable pharmacodynamic effect presents a favorable product profile. This novel and differentiated mechanism of action has the potential to improve efficacy while significantly reducing the toxicity of the drug in monotherapy and combo-therapy.