On June 1, 2021 CBMG Holdings, a biopharmaceutical company developing innovative cellular immunotherapies for the treatment of cancer, reported the publication of two abstracts of CAR-T therapies for liquid tumors published in conjunction with the 2021 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, to be held June 4-8, 2021 (Press release, Cellular Biomedicine Group, JUN 1, 2021, View Source [SID1234583363]). These abstracts will be presented at the upcoming ASCO (Free ASCO Whitepaper) meeting as podium presentations.
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Session: Developmental Therapeutics—Immunotherapy
Abstract #: 2507
Citation: J Clin Oncol 39, 2021 (suppl 15; abstr 2507)
DOI: 0.1200/JCO.2021.39.15_suppl.2507
Drug name: C-CAR039
Mechanism of Action: A 2nd generation novel bi-specific CAR-T therapy targeting both CD19 and CD20 antigens
Indications: Relapsed/refractory B-cell non-Hodgkin’s lymphoma (B-NHL)
C-CAR039 has been developed as a novel 2nd generation 4-1BB bi-specific CAR-T targeting both CD19 and CD20 antigens with an optimized bi-specific antigen binding domain. C-CAR039 can eradicate CD19/CD20 single or double positive tumor cells in vitro and invivo. The tissue cross reactivity and whole genome membrane proteome array studies further confirmed the specificity of C-CAR039.
C-CAR039 demonstrated a favorable safety profile and promising efficacy in this early clinical trial in patients with r/r B-NHL that might allow it to differentiate from existing therapies. The early clinical efficacy signal is encouraging and compares favorably to anti-CD19 CAR-T and peer therapies. These findings will be evaluated in more patients with longer follow-up to confirm safety, efficacy and duration of response. Clinical trial information: NCT04317885, NCT04655677, NCT04696432, NCT04693676.
View full abstract here
Session: Developmental Therapeutics—Immunotherapy
Abstract #: 2508
Citation: J Clin Oncol 39, 2021 (suppl 15; abstr 2508)
DOI: 10.1200/JCO.2021.39.15_suppl.2508
Drug name: C-CAR066
Mechanism of Action: A novel 2nd generation CAR-T therapy targeting CD20 antigen
Indications: Relapsed/refractory B-cell non-Hodgkin lymphoma (r/r B-NHL) that has failed to an anti-CD19 CAR-T therapy
A phase I clinical trial was conducted to evaluate the safety and efficacy of C-CAR066 in subjects with r/r B-NHL who were previously treated with anti-CD19 CAR-T therapy. Patients (≥ 18 years) with r/r DLBCL, r/r FL or r/r MCL, ECOG < 2 were eligible. GMP manufacture of C-CAR066 was in a serum free and fully closed semi-automatic system. A 3-day cyclophosphamide plus fludarabine regimen was followed by a single infusion of C-CAR066. Bridging therapy was allowed.
C-CAR066 has shown a favorable safety profile and promising efficacy in patients with r/r B-NHL following failure of CD19 CAR-T therapy. These results show that C-CAR066 has a different mechanism of action compared to anti-CD-19 CAR-T therapy and could provide a solution to address the unmet medical need in B-NHL patients that have failed anti-CD19 CAR-T therapy. Clinical trial information: NCT04036019