On May 26, 2021 Humanigen, Inc. (Nasdaq: HGEN), a clinical-stage biopharmaceutical company focused on preventing and treating an immune hyper-response called ‘cytokine storm’ with its lead drug candidate, lenzilumab, reported that granulocyte macrophage-colony stimulating factor (GM-CSF) gene-edited CAR-T data will be presented at the International Society for Cell & Gene Therapy (ISCT) 2021 Annual Meeting which will be held in New Orleans from May 26- 28, 2021 (Press release, Humanigen, MAY 26, 2021, View Source [SID1234580641]).
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Researchers at the Mayo Clinic, Rochester, MN have demonstrated that CRISPR/Cas9 GM-CSF knock-out in CAR-T cells (GM-CSFKO CAR-T) dampens CAR-T cell early activation and reduces activation-induced cell death (AICD), resulting in enhanced antigen-specific T-cell expansion in vivo. The modulation of intrinsic pathways is not due to an off-target effect and provides additional mechanistic rationale for the improved anti-tumor activity observed with GM-CSFKO CAR-T.
"These findings highlight the intrinsic value of GM-CSFKO CAR-T as a novel, potentially more effective and less toxic platform to enhance current CAR-T cell therapies," said Cameron Durrant, MD, MBA, chief executive officer of Humanigen.
Mayo Clinic researchers will present their research entitled, "GM-CSF disruption in CAR-T cells ameliorates CAR-T cell activation and reduces activation-induced cell death," on May 28, 2021 from 11:30 AM to 1:00 PM ET as part of the session titled "Novel Allo-Engineering Approaches and Progress in Off-the-Shelf Products."
"Mayo Clinic is enthusiastic about these findings, and they provide us with valuable information to enhance our current CAR-T cell therapies," said Saad S. Kenderian, MD, Division of Hematology, Mayo Clinic.
Details for the upcoming event are below:
ISCT 2021 New Orleans VIRTUAL Meeting
Novel Allo-Engineering Approaches and Progress in Off-the-Shelf Products Session
Date: Friday, May 28, 2021
Time: 11:30 AM ET