On December 10, 2018 QED Therapeutics reported that it has entered into an agreement with Foundation Medicine to develop a companion diagnostic for infigratinib, an FGFR1-3 selective tyrosine kinase inhibitor, in patients with cholangiocarcinoma (Press release, QED Therapeutics, DEC 10, 2018, View Source [SID1234576269]). The companion diagnostic, which will include detection of activating FGFR2 fusions, is expected to be incorporated into FoundationOneCDx, Foundation Medicine’s FDA-approved comprehensive genomic profiling (CGP) assay for all solid tumors that includes multiple companion diagnostics.

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"While targeted therapies have transformed the treatment landscape for multiple cancers, such as lung cancer, cholangiocarcinoma has not yet benefitted from these advances," noted Susan Moran, M.D., M.S.C.E., chief medical officer of QED Therapeutics. "Given infigratinib’s demonstrated promise in FGFR2 fusion-driven cholangiocarcinoma, a companion diagnostic is critical to help physicians reliably identify which patients might be candidates for treatment."