On December 31, 2020 Nimbus Therapeutics, a biotechnology company designing breakthrough medicines through structure-based drug discovery and development, reported that it has regained the worldwide rights to its HPK1 inhibitor program from Bristol Myers Squibb (Press release, Nimbus Therapeutics, DEC 31, 2020, View Source [SID1234573335]). Under Nimbus’ agreement with Celgene, now a Bristol Myers Squibb company, Celgene held an option to acquire the HPK1 inhibitor program. As part of its Celgene integration process, Bristol Myers Squibb is streamlining and prioritizing its portfolio and as a result, made the decision to decline this option.

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"We’re excited to continue progressing our small molecule HPK1 inhibitors within Nimbus’ wholly owned pipeline. Preclinical data we presented this year at prominent oncology conferences show that our potent HPK1 inhibitor has a high degree of selectivity, demonstrates in vitro effects on T cells, B cells and dendritic cells, and shows significant in vivo tumor growth inhibition across multiple animal models," said Peter Tummino, Ph.D., Chief Scientific Officer of Nimbus. "We look forward to progressing this promising immuno-oncology program into a first-in-human clinical study in 2021."