On September 22, 2020 IMMUNOPRECISE ANTIBODIES LTD. (the "Company" or "IPA") (TSX VENTURE: IPA) (OTCQB: IPATF) (FSE:TQB2), a leader in full-service, therapeutic antibody discovery and development, reported that its subsidiary, IPA Europe, has made a substantial investment in its B-Cell Select platform at its research division in Oss, The Netherlands, enabled by investments in additional equipment to automate and significantly innovate their multi-species, target-interaction-based single B-cell selection technology and subsequent single cell cloning, thereby significantly accelerating the identification of comprehensive panels of diverse lead therapeutic antibodies (Press release, ImmunoPrecise Antibodies, SEP 22, 2020, View Source [SID1234565480]). The advanced B Cell Select platform seamlessly integrates into IPA’s optimization and antibody developability profiling workflow.
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"Our dedicated and motivated team members are driving the success our B Cell Select platform expansion. This powerful, multi-species platform is combined with direct, single B cell cloning and antibody binding profiling to rapidly identify highly diverse, clinically relevant antibodies to treat various diseases involving a broad variety of complex target antigens." stated Debby Kruijsen, General Manager of IPA Europe.
"Next to its suitability for a broad range of antibody sources, our advanced B Cell Select platform is also compatible with various target tools, including target-expressing cells, enabling us to select clones at an early stage of antibody discovery based on a functional read-out as well." says Ilse Roodink, Scientific Director of IPA-EU.
Interested in learning more? Our second-generation B Cell Select platform will be one of IPA’s showcased technologies presented at our webinar "High-Throughput Identification of Genetically Distinct, Target-Specific Antibodies", airing September 23rd at 11:00 EDT. Click here to register online.
About B Cell Select
ImmunoPrecise Antibodies’ B Cell Select platform enables the interrogation of a greater diversity of an antibody repertoire than otherwise possible. By interrogating isolated B-cells, IPA can analyze full organism repertoires with very little manipulation. This proprietary platform is species independent allowing for the generation of antibodies from samples not possible using other methods. B Cell Select can develop antibodies from any species (including humans) as well as from any tissue. As the platform explores the entire antibody repertoire, it can develop antibodies for anything that is possible in an animal’s immune repertoire including any protein class, complex therapeutic targets, post-translational modifications, and small molecules.
The B Cell Select platform enables the interrogation of 10 million blood cells to generate native monoclonal antibodies from immunized animals that specifically target an antigen. The B cell selection process takes place early in the antibody development process allowing for the rapid selection of top candidates, drastically increasing the success rate of antibody discovery. The platform also harnesses the power of the immune system to generate natural pairing of the antibodies produced by selected B cells. These deliverables in our discovery programs have less liabilities within the antibody sequences compared to unnatural pairs from in vitro screening that could potentially affect manufacturability of the antibodies.