On June 30, 2020 Corcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of drugs to treat severe metabolic, oncologic and psychiatric disorders by modulating the effects of cortisol, reported enrollment of the first patient in RELIANT, an open-label, Phase 3 trial of relacorilant in combination with nab-paclitaxel (Celgene’s medication, Abraxane) in patients with metastatic pancreatic cancer (Press release, Corcept Therapeutics, JUN 30, 2020, https://ir.corcept.com/news-releases/news-release-details/corcept-therapeutics-initiates-phase-3-trial-relacorilant-plus [SID1234561572]).
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"Metastatic pancreatic cancer is an aggressive disease and there is an urgent need for effective therapies," said Andreas Grauer, MD, Corcept’s Chief Medical Officer. "Cortisol activity suppresses apoptosis. Relacorilant reverses this effect and may enable chemotherapeutic agents such as nab-palitaxel to achieve their full, cancer-killing effect. The results of our open-label, Phase 1/2 study, which we presented at ASCO (Free ASCO Whitepaper) last year, were very encouraging.1 We are excited to have begun this larger, more definitive trial. We believe sufficiently positive results would support accelerated approval."
RELIANT has a planned enrollment of 80 patients with metastatic pancreatic cancer, with an interim analysis of data from the first 40 patients. Each patient will receive relacorilant plus nab-paclitaxel. The primary endpoint is objective response rate. Secondary endpoints include progression-free survival and duration of response. RELIANT will be conducted at 20 sites in the United States.2
About Relacorilant
Relacorilant is a non-steroidal, selective modulator of the glucocorticoid receptor that does not bind to the body’s other hormone receptors. Corcept is studying relacorilant in a variety of serious disorders, including Cushing’s syndrome and adrenal, ovarian and pancreatic cancer. Relacorilant is proprietary to Corcept and is protected by composition of matter and method of use patents. Relacorilant has received orphan drug designation in the United States for the treatment of Cushing’s syndrome and pancreatic cancer.