On May 28, 2020 Tyme Technologies, Inc. (NASDAQ: TYME), an emerging biotechnology company developing cancer metabolism-based therapies (CMBTs), reported that two abstracts will be published at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) 2020 Virtual Meeting to be held from May 29 to May 31 (Press release, TYME, MAY 28, 2020, View Source [SID1234558635]).

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CMBTs are proprietary investigational compounds that leverages cancer’s altered metabolism and associated vulnerabilities to specifically disrupt fundamental cellular processes. This can include altering protein synthesis, increasing oxidative stress, decreasing pH levels, and compromising protein or lipid barriers. In addition, CMBTs may target select survival mechanisms including autophagy, as well as altering the tumor microenvironment to improve immune recognition of the cancer.

In clinical trials, our lead cancer metabolism-based compound, SM-88 (racemetyrosine), has demonstrated encouraging tumor responses across 15 different cancers, including pancreatic, prostate, sarcoma, breast, lung, and lymphoma cancers with minimal serious grade 3 or higher adverse events.

Radiomics Abstract:

SM-88 is an oral dysfunctional tyrosine derivative. Previous studies reported a well-tolerated profile with encouraging efficacy. Recently, advances in image analysis using quantitative textural analysis have uncovered noninvasive biomarkers that correlate with molecular drivers of cancer and prognostic signatures of response. Earlier radiomic data from patients treated with SM-88 showed a positive correlation between circulating tumor cells and tumor radiomics at baseline. This study extends those findings to focus on radiomic changes associated with SM-88 in a Phase II dose escalation trial (NCT03512756).

Health Economic Outcomes Research Abstract:

Over the past 20 years, innovative cancer medicines have contributed to increased life expectancy, reduced mortality, decreased hospitalization and decreased use of medical services. Recently, a health economic study presented at ASCO (Free ASCO Whitepaper) GI 2020 cited that for every additional $1 spent on innovative medicines for pancreatic cancer between 2009 and 2016, there was a reduction in non-medicine spending of $8 to $9, thereby lowering the total cost of care for pancreatic cancer patients. Accordingly, the commercial opportunity of a new disease-altering therapy should be measured by some combination of the clinical, economic and social value created. This study demonstrates the value of a novel pancreatic cancer therapy from this perspective.

Additional information on the meeting can be found on the ASCO (Free ASCO Whitepaper) website at: View Source

Details for the abstracts are as follows

Title: Radiomic texture analysis correlates with PDAC patient outcomes on SM-88
Virtual Session: Gastrointestinal Cancer – Gastroesophageal, Pancreatic and Hepatobiliary
Virtual Session Date: May 29-31, 2020
Virtual Session Location: ASCO (Free ASCO Whitepaper) Virtual Scientific Program
Abstract Number: e16776

Title: Value-Based Estimate of Market Size and Opportunity for Economic Benefit Through Innovative Pancreatic Cancer Therapies
Virtual Session: Gastrointestinal Cancer – Gastroesophageal, Pancreatic and Hepatobiliary
Virtual Session Date/Time: May 29-31, 2020
Virtual Session Location: ASCO (Free ASCO Whitepaper) Virtual Scientific Program
Abstract Number: e16790

About SM-88

SM-88 is an oral investigational modified proprietary tyrosine derivative that is believed to interrupt the metabolic processes of cancer cells by breaking down the cells’ key defenses and leading to cell death through oxidative stress and exposure to the body’s natural immune system. Clinical trial data have shown that SM-88 has demonstrated encouraging tumor responses across 15 different cancers, including pancreatic, lung, breast, prostate and sarcoma cancers with minimal serious grade 3 or higher adverse events.