On March 25, 2020 Agios Pharmaceuticals, Inc. (NASDAQ: AGIO) reported an update on its 2016 collaboration agreement with Celgene Corporation, a wholly owned subsidiary of Bristol Myers Squibb Company (Press release, Agios Pharmaceuticals, MAR 25, 2020, View Source [SID1234555819]). Celgene has formally declined to exercise its opt-in right for AG-270, a first-in-class methionine adenosyltransferase 2a (MAT2A) inhibitor development candidate currently in a Phase 1 study in combination with taxane-based therapy as a potential treatment for methylthioadenosine phosphorylase (MTAP)-deleted non-small cell lung cancer and pancreatic cancer. In addition, the research term of the companies’ metabolic immuno-oncology collaboration, focused on altering the metabolic state of immune cells to enhance the body’s immune response to cancer, will conclude at the end of the initial four-year period in May 2020. There is one undisclosed, ongoing metabolic immuno-oncology research program that Celgene may designate for continued development within sixty days following the end of the research term; if it does so, Celgene would have an opt-in right for this program through the end of Phase 1 dose escalation.
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"We are grateful to Celgene, and now Bristol Myers Squibb, for their longstanding partnership, which has enabled important research and clinical development focused on the advancement of potential innovative treatment approaches for patients with cancer," said Jackie Fouse, Ph.D., chief executive officer at Agios. "We are now evolving our relationship to enable both companies to advance our respective priorities with full strategic flexibility."
"We are proud of the work our scientists have done to significantly advance knowledge in the field of metabolic immuno-oncology, and through these efforts we have built capabilities now being applied across multiple research programs," said Bruce Car, Ph.D., chief scientific officer at Agios. "We will leverage the insights gained under the Celgene collaboration to continue our research efforts in this area in a strategic and targeted manner. Moving forward, Agios retains full rights to the output of our discovery engine and can optimize our allocation of resources as we strive to discover drug candidates with the potential to improve the lives of patients with cancer and rare genetic diseases."
About the MAT2A Inhibitor AG-270
Agios’ first-in-class MAT2A inhibitor, AG-270, was part of a 2016 global research collaboration agreement with Celgene. Under the terms of the agreement, Celgene had an opt-in right on the program up through the end of Phase 1 dose escalation for at least a $30 million fee.
As described in a 2016 Cell Reports publication, Agios discovered that MAT2A is a component of a novel pathway which, when inhibited, results in robust anti-tumor activity in MTAP-deleted tumors in animal models. Further preclinical studies demonstrated that the effects of AG-270 downstream of MAT2A inhibition include effects on mitosis, which creates the potential for enhanced vulnerability to antimitotics, including the clinically-applicable taxanes.
The first data from the single agent dose-escalation arm of the Phase 1 study of AG-270 in MTAP-deleted tumors were presented at the 2019 AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper), which demonstrated that AG-270 induces reductions in the biomarkers of MAT2A inhibition, notably plasma concentrations of S-adenosylmethionine (SAM) and tumor levels of symmetrically demethylated arginine (SDMA), at well tolerated doses. The Phase 1 trial is ongoing in cohorts exploring the safety and preliminary efficacy of AG-270 in combination with taxanes in non-small cell lung cancer and pancreatic cancer.
About the 2016 Metabolic Immuno-Oncology Agreement
In May 2016, Agios and Celgene entered into the 2016 Metabolic Immuno-Oncology Agreement, a global strategic collaboration focused on discovering, developing and commercializing novel therapies based on Agios’ innovative cellular metabolism research platform.
There is one ongoing research program that Celgene may designate for continued development within 60 days following the end of the initial four-year research term, which expires on May 17, 2020, by paying an $8 million designation fee. Agios may conduct further research and preclinical and clinical development activities on this program, at its expense, through the completion of an initial Phase 1 dose escalation study, at which point Celgene has an opt-in right for this program for at least a $30 million fee.