On March 15, 2018 Nordic Nanovector ASA (OSE: NANO) reported that it will present a poster reporting the anti-tumour effect of Humalutin (177Lu-conjugated humanized anti-CD37 antibody, 177Lu-NNV003) in preclinical models of non-Hodgkin’s lymphoma (NHL) at the American Association of Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2018 (Press release, Nordic Nanovector, MAR 15, 2018, View Source [SID1234553509]). The meeting takes place from 14-18 April in Chicago, USA.
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The preclinical data to be presented, described in an abstract published yesterday (link), demonstrate that:
In tumour cell lines:
• The unlabelled anti-CD37 antibody (NNV003) kills tumour cells mainly through an immunological process called antibody dependent cellular cytotoxicity
• Humalutin (177Lu-NNV003) was found to inhibit tumour cell growth.
In preclinical lymphoma models:
• Humalutin has shown significant tumour uptake and demonstrated an anti-tumour effect in all three NHL models (mantle cell lymphoma, diffuse large B-cell lymphoma and chronic lymphocytic leukaemia).
Jostein Dahle, Chief Scientific Officer commented: "The data is important for Nordic Nanovector as they provide an early demonstration of the potential that Humalutin has for treating different types of NHL. These encouraging data provide further support to the planned clinical development of Humalutin, for which Nordic Nanovector expects to launch a Phase I study in NHL in the second half of 2018."
Details for the poster presentation are as follows:
Poster Title: In vitro and in vivo evaluation of the beta-emitting lutetium-177 labeled anti-CD37 antibody radionuclide conjugate 177Lu-NNV003 in DLBCL, CLL and MCL models Session Date and Time: Sunday 15 April 2018, 1:00 PM – 5:00 PM (Central Time) Location: McCormick Place South, Exhibit Hall A, Poster Section 39, Poster Board Number: 11 Session Category: Experimental and Molecular Therapeutics Session Title: Modulators of Ionizing Radiation and Other Radiotherapeutics Permanent Abstract Number: 848
The poster will be available on 15 April 2018 on the company’s website at: www.nordicnanovector.com.