On June 6, 2019 Nordic Nanovector ASA (OSE: NANO) reported that its Chief Scientific Officer, Jostein Dahle, will present results from preclinical studies with 212PB-NNV003, a novel Targeted Alpha Therapy comprising its proprietary CD37-specific antibody (NNV003) coupled with the alpha-particle generating radioisotope lead-212 (212Pb) in models of chronic lymphocytic leukaemia (CLL) and non-Hodgkin lymphoma (NHL) at the Targeted Radiopharmaceuticals Summit taking place in Munich, Germany on 12-13 June (Press release, Nordic Nanovector, JUN 6, 2019, View Source [SID1234553448]).

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The presentation will take place at 13th June 09:30-10:00 CEST and is entitled:

Targeted alpha therapy with 212Pb-NNV003 for the treatment of CD37 positive B-cell chronic lymphocytic leukaemia (CLL) and non-Hodgkin lymphoma (NHL)

CD37 is highly and selectively expressed on the surface of mature B lymphocytes and B-cell malignancies and may become a useful alternative to the CD20 target, due to the emergence of resistance to anti-CD20 therapies.

Alpha-emitting radionuclides have demonstrated good potential for cancer targeted therapies because of short-range alpha energy deposition (50–100 µm) that causes irreparable DNA double-strand breaks and localized cytotoxicity while sparing surrounding healthy tissues.

The targeted alpha therapy 212Pb-NNV003 has been developed under a collaboration between Nordic Nanovector and Orano Med.