On December 18, 2019 BioInvent International AB ("BioInvent" or the "Company") (OMXS: BINV) reported that it has entered into a clinical trial collaboration and supply agreement with MSD, a tradename of Merck & Co., Inc., Kenilworth, NJ., USA, to evaluate the combination of BioInvent’s BI-1206, one of its proprietary anti-FcγRllB antibodies and MSD’s anti-PD-1 therapy, KEYTRUDA (pembrolizumab) in a Phase l/lla clinical trial for patients with solid tumors (Press release, BioInvent, DEC 18, 2019, View Source [SID1234552475]).
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Martin Welschof, CEO of BioInvent, said, "We are very pleased to have concluded this agreement with Merck, which helps us to expand BI-1206 clinical development to solid tumors in combination with one of the most powerful and successful immune-oncology drugs. This will enable us to build on recent preclinical data which demonstrates BI-1206’s ability to address an important mechanism of resistance to PD-1 inhibition."
The Phase l/lla clinical trial will evaluate the drug combination in patients with advanced solid tumors, who have been previously treated with anti-PD-1 or anti-PD-L1 antibodies, and is a multicenter, dose-finding, consecutive-cohort, open-label trial. BI-1206 is currently being investigated in non-Hodgkin lymphoma and chronic lymphocytic leukemia.
KEYTRUDA is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.