On December 9, 2019 ImaginAb, Inc., a clinical-stage immuno-oncology imaging company, reported it has initiated its Phase II clinical trial of its lead product, CD8 tracer 89Zr-Df-IAB22M2C, at Penn Medicine in Philadelphia, PA (Press release, ImaginAb, DEC 9, 2019, View Source [SID1234552119]). Penn Medicine is one of the world’s leading academic medical centers.
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89Zr-Df-IAB22M2C is a first in class imaging agent that visualizes the immune system using non-invasive, whole-body in vivo PET imaging of CD8 T cells. Using its ‘Minibody’ platform, ImaginAb’s technology targets and visualizes CD8+ T-cells to provide highly-specific, quantitative assessment of the immunological status of each cancer lesion within a patient, potentially enabling treatment to be tailored quickly and specifically to the needs of that patient.
Penn Medicine is one of ImaginAb’s active clinical sites conducting Phase II Baseline/On-Treatment clinical trial investigating the utility of 89Zr-Df-IAB22M2C to image CD8 T cells prior to (Baseline) and after (On-treatment) cancer patients receive immunotherapy-based treatment. Michael Farwell, MD, an Assistant Professor of Radiology in the Perelman School of Medicine at the University of Pennsylvania, is the study’s principal investigator.
Ian Wilson, CEO of ImaginAb, said: "ImaginAb’s goal is to provide target-specific imaging agents to evaluate immune responses in cancer patients in a safe and non-invasive manner and help realize the full potential of immunotherapy. We are delighted to add Penn Medicine to our CD8 Imaging Phase II trial and for enrollment in this ongoing clinical study."
The trial will enroll advanced and metastatic cancer patients and will study the correlation of imaging signals observed using ImaginAb’s CD8 T cell ImmunoPET imaging agent, standard-of-care scans, and immunohistochemistry analysis of CD8 in biopsied tissues. The trial will also measure changes in CD8+ T-cell distribution before and after immuno-oncology therapies.