On October 26, 2019 Adagene, Inc., a clinical stage biotech company with innovative antibody discovery and engineering technologies, reported that it is presenting its lead program at international conferences (Press release, Adagene, OCT 26, 2019, View Source [SID1234548675]).
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
During the Festival of Biologics conference in Basel, Switzerland, Adagene gave a presentation on "Targeting the conserved epitopes of check points for rational single and combination immunotherapy", highlighting the unique power of Adagene’s proprietary antibody discovery technology, Dynamic Precision Library (DPL), in generating species cross-reactive antibodies to enable translational studies in immune intact animal models. The DPL system combines extensive computational design, machine learning and high throughput phage and yeast screening to generate cross-reactive antibodies targeting evolutionarily conserved epitopes with novel mechanism of actions and excellent developability.
A case study of ADG106, a species cross reactive agonist antibody which targets the conserved epitope of CD137 across human, monkey and mouse. ADG106 activates CD137 in a native ligand-like fashion, while it also blocks the reverse signaling mediated by CD137 ligand. Furthermore, ADG106 is shown to exhibit Fc-mediated strong crosslinking. ADG106 has been extensively tested for efficacy in both single and combination therapy using syngeneic mouse tumor models that are believed to be relevant preclinical models of intact immune system and highly translatable into a rational approach toward single and combination immunotherapies.
The clinical data from the ongoing phase 1, first-in-human, dose-escalation study of ADG106, will be presented in a poster session at the 2019 AACR (Free AACR Whitepaper)-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference in Boston, Massachusetts. The Phase 1 study in the United States, First-In-Human study of ADG106 in subjects with advanced or metastatic solid tumors and/or relapsed/refractory non-Hodgkin lymphoma (NCT02407990) is being conducted at NEXT Oncology (San Antonio, Texas), and consists of dose-escalation and dose-expansion phases in disease-specific cohorts.