On September 16, 2019 INmune Bio, Inc. (NASDAQ: INMB), an immunology company focused on developing treatments that harness the patient’s innate immune system to fight disease, reported that RJ Tesi, M.D., Co-Founder and CEO, and Mark Lowdell, Ph.D., Co-Founder and Chief Scientific Officer, will present at the first ever Targeting Innate Immunity Congress, taking place in the biotech hub of Cambridge, Mass. from Sept. 23 through 25 (Press release, INmune Bio, SEP 16, 2019, View Source [SID1234539636]).
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The conference is an opportunity for INmune Bio to showcase its two leading innate compounds in the hopes of improving the treatment of cancer to industry leaders, experts, academic researchers and clinicians in the field of innate immunity. In addition to presenting at the conference, Dr. Tesi and Dr. Lowdell will be instructing a course on the role of the tumor microenvironment (TME) in immunosuppression.
"This panel will bring together other experts from industry and academia to explore the role of the innate immune system in the TME and in cancer drug development," said Dr. Tesi.
In addition to speaking at the Targeting Innate Immunity Congress this month, Dr. Tesi will also take part in a speaking engagement at the second annual MarketsandMarkets Next Gen Immuno-Oncology Congress on Sept. 19 in Philadelphia.
Below is a schedule of upcoming presentations:
MarketsandMarkets Next Gen Immuno-Oncology Congress
Thursday, September 19 at 11:40 a.m.
"Reversing Trastuzumab Resistance in HER2+ Breast Cancer"
Dr. Tesi will discuss Mucin 4 (MUC4) protein and how it predicts trastuzumab resistance in HER2+ breast cancer, the role of soluble tumor necrosis factor (TNF) in MUC4 expression and how INmune Bio’s drug candidate, INB03 works in combination with trastuzumab to reverse resistance in MUC4/HER+ breast cancer.
Targeting Innate Immunity Congress
Monday, September 24 at 3:30 – 6:00 p.m.
Short Course: "Understanding and Modulating Tumor Microenvironment for Immunotherapy"
Dr. Tesi and Dr. Lowdell will instruct an interactive short course on the role of the tumor microenvironment (TME) in immunosuppression. They will discuss strategies to change the immunosuppressive nature of the TME to one that supports immune responses and enhances the impact of tumor immunotherapy. Those who attend will walk away with an understanding of the following:
•Role of the TME in immunosuppression
•Checkpoint inhibitor optimization
Targeting of regulatory cells
•Reprogramming of immunosuppressive cells
•Modulation of chemokines and cytokines in the TME
•Modification of tumor-reactive lymphocytes to evade the TME
Wednesday, September 25 at 11:40 a.m.
"Myeloid Derived Suppressor Cell (MDSC): The Queen Bee of the Tumor Microenvironment (TME)"
As part of the "Modulating Macrophages in the Tumor Microenvironment" panel, Dr. Tesi will discuss targeting myeloid derived suppressor cells (MDSCs) as an efficient way to reverse tumor microenvironment (TME) immunobiology. His discussion will address the complexity of TME and how it contributes to failure of therapy, as well as understanding how targeting soluble tumor necrosis factor (TNF) offers a solution to the resistance to therapy when part of combination therapy. Dr. Tesi will also discuss the results of the Phase I trial for INmune Bio’s drug candidate, INB03 in patients with advanced cancer.
Wednesday, September 25 at 1:45 p.m.
"What do Tumor Cells do to NK Cells? – Harnessing the Tumor-NK Interaction for Clinical Benefit"
Dr. Lowdell will participate in the "Advancing Innate Cell Therapies to the Clinic" portion of the conference to discuss how relapsed cancer cells evade natural killer (NK) cells, and how priming NK cells could effectively kill these cancer cells. Dr. Lowdell will also discuss INmune Bio’s INKmune drug candidate.