On September 16, 2019 Onconova Therapeutics, Inc. (NASDAQ:ONTX), a Phase 3-stage biopharmaceutical company discovering and developing novel products to treat cancer, with a focus on myelodysplastic syndromes (MDS),reported that it will present at the RAS-Targeted Drug Discovery Summit being held September 17-19 in Boston, Massachusetts (Press release, Onconova, SEP 16, 2019, View Source [SID1234539548]). Dr. Steven Fruchtman, President & CEO, will be presenting. Also attending the conference will be Avi Oler, VP Corporate Development.
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ABOUT RAS AND RIGOSERTIB:
There is a high frequency of Ras mutations in cancer that leads to the belief that mutations of the Ras Pathway provide a proliferative advantage and thus is involved in the pathogenesis of cancer. As a result, targeting the Ras pathway has been the objective of scientific research for decades. As published in the journal Cell in 2016, and now under investigation in a pivotal Phase 3 Trial, rigosertib targets the mutated RAS pathway by its interaction with Ras effector proteins containing the Ras Binding Domain. The RAS-Targeted Drug Discovery Summit provides an opportunity to showcase the potential for rigosertib in MDS and in other RAS-driven cancers, such as KRAS-mutated lung cancer and colorectal cancer, and Ras- driven pediatric cancers as well. Onconova will review its INSPIRE Trial for which the Company anticipates reporting top-line data for second-line, higher-risk MDS patients in the first half of 2020 following full enrollment and 288 death events. Onconova’s representatives look forward to joining colleagues at the Summit to discuss advancements in rigosertib’s development and the progress the Company and others have made in targeting RAS.
DETAILS OF THE PRESENTATION:
Title: Rigosertib: Targeting the Ras+ Pathway and Clinical Trials in MDS and Beyond
Date/Time: Thursday, September 19th, 10:30 a.m.
Presenter: Steven M. Fruchtman, M.D.