On August 28, 2018 GT Biopharma Inc. (GTBP) (Euronext Paris: GTBP.PA) reported the initiation of a combination trial of OXS-1550 and multi-billion dollar oncology drug, owned by a major Pharmaceutical Company (the Company) (Press release, GT Biopharma , AUG 28, 2018, View Source [SID1234539524]). This effort is headed by Dr. Daniel Vallera, Director, Section of Molecular Cancer Therapeutics at the Masonic Cancer Center, University of Minnesota. Under this Material Transfer Agreement (MTA) announced on July 19, 2018 between GT Biopharma, Inc and the Company, Dr. Vallera has been supplied with a formulation of their this widely prescribed drug approved for use in several hematologic malignancies for preclinical studies.
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Dr. Daniel Vallera said: "Based on our exciting preliminary in vitro experiments, the initial preclinical work suggests a much greater effect when OXS-1550 is given with this drug. We are very excited about our progress with GT’s OXS-1550 (DT2219) combined with ibrutinib, a potent small molecule Bruton Tyrosine Kinase (BTK) inhibitor which is already an established chemotherapeutic agent. We believe combination therapies like these that kill cancer cells based on entirely different mechanisms are the future of cancer treatment."
Dr. Vallera is the lead researcher for GT Biopharma’s bispecific antibody drug conjugate (ADC) program, and the innovator of DT2219, also known as OXS-1550. OXS-1550 is a bispecific antibody drug conjugate which means it targets two antigens on cancer cells and contains a cytotoxic payload thereby increasing the probability it will kill the cancer cells. OXS-1550 targets cancer cells expressing the CD19 receptor and/or CD22 receptors which includes B-cell leukemias and lymphomas and has a modified form of diphtheria toxin (DT390) as its cytotoxic drug payload. After OXS-1550 binds to cancer cells, it is taken in by the cancer cells and subsequently deploy its cytotoxic diphtheria toxin payload which inhibits protein synthesis and kills the cancer cells.