On June 26, 2019 Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM) ("Actinium") reported that a poster detailing Actinium’s preclinical work with the CD38 antibody daratumumab, a blockbuster therapy marketed as Darzalex by Johnson & Johnson for patients with Multiple Myeloma, labeled with the radioisotope Ac-225 or Actinium-225 has been selected as a top poster at SNMMI for inclusion in a competitive poster competition at the 2019 Society of Nuclear Medicine and Molecular Imaging Annual Meeting (Press release, Actinium Pharmaceuticals, JUN 26, 2019, View Source [SID1234537269]). The poster titled, "225AC-CD38 antibody targeting is effective and well tolerated in experimental models of lymphoma and multiple myeloma" was selected from more than 1,100 posters that were presented at this year’s SNMMI and awarded second place in the Oncology: Basic, Translational & Therapy track (Click here for poster).
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Highlights from the poster include:
Ac-225 labeled daratumumab, at an equimolar concentration, demonstrated superior antitumor activity to naked daratumumab in DAUDI lymphoma tumor xenograft model and provided a survival benefit
Tumor cell death in cell culture was increased as much as ten-fold following exposure to Ac-225 labeled daratumumab, approaching one-hundred percent cell death in certain cell lines
Immunoreactivity for the target antigen CD38 was similar to naked daratumumab demonstrating that arming the antibody with Ac-225 preserved daratumumab’s CD38 targeting ability
Dr. Dale Ludwig, Actinium’s Chief Scientific Officer, presented the poster at SNMMI.
Actinium’s AWE or Antibody Warhead Enabling technology platform generated the Ac-225 daratumumab ARC or Antibody Radiation-Conjugate. Actinium’s AWE platform is covered by know-how and trade secrets that cover the generation, development, methods of use and manufacturing of ARC’s. Actinium’s AWE intellectual property portfolio is comprised of 28 patent families and over 100 issued and pending patents having useful life extending out as far as 2039.
Dr. Ludwig commented, "We are honored that our poster was recognized for this competition from the over 1,100 posters and great work that was presented at this year’s SNMMI. It was apparent from SNMMI that the radiopharmaceutical field, particularly targeted radiotherapies, is experiencing significant growth and rapid innovation. Actinium is dedicated to staying at the forefront of the field. Our commitment is evidenced by our expanded research efforts that have resulted in a significant number of new patent filings and presentations at international conferences. Further, our active research collaboration with Astellas Pharma is ongoing and we are working to complete the third and final module of the program. Through our AWE technology platform, we have demonstrated the ability to utilize multiple isotopes with multiple targeting agents to generate potent ARCs, giving us unmatched breadth and abilities in therapeutics discovery and development. Together with Actinium’s clinical experience and comprehensive supply chain capabilities, we can offer partners and collaborators a turnkey solution from R&D to the clinic and beyond."