On September 19, 2016 Sutro Biopharma reported that it has presented findings from two studies of investigational antibody drug conjugates, or ADCs, that it developed to target CD74, a protein highly expressed in hematologic malignancies (Press release, Sutro Biopharma, SEP 19, 2016, View Source [SID1234516951]). The ADCs demonstrated efficient cell killing in multiple malignant B-cell lines and suppressed tumor growth in six mouse tumor models of non-Hodgkin lymphoma and multiple myeloma. The findings were presented Friday, September 16 at the 2016 American Society of Hematology (ASH) (Free ASH Whitepaper) Meeting on Hematologic Malignancies in Chicago.
"The findings demonstrate that CD74 is an ideal target for Sutro’s novel antibody drug conjugates and underscore how we’re accelerating ADC development using Sutro’s proprietary cell-free platform through the late preclinical phase and towards the clinic," Sutro CEO Bill Newell said.
Sutro’s novel ADCs efficiently killed multiple myeloma, mantle cell lymphoma, diffuse large B-cell lymphoma and other Non-Hodgkin lymphoma cell lines in vitro. In vivo, these ADCs significantly reduced tumor growth in ANBL-6, CAG and ARP-1 multiple myeloma models and WSU-DLCL2, OCI-Ly10, SU-DHL-6 lymphoma models.

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