On July 07, 2016 Heat Biologics, Inc. (Nasdaq:HTBX), an immuno-oncology company developing novel therapies that activate a patient’s immune system against cancer, reported that a preclinical study on its next generation ComPACT platform technology, which combines a T cell priming vaccine and T cell co-stimulator in a single product, was published online in the journal "Cancer Immunology Research (Press release, Heat Biologics, JUL 7, 2016, View Source [SID:1234513758])." In the manuscript titled "Gp96-Ig/costimulator (OX40L, ICOSL or 4-1BBL) combination vaccine improves T-cell priming and enhances immunity, memory and tumor elimination," Heat demonstrated that its ComPACT technology secreting the co-stimulator OX40L significantly enhanced tumor rejection in two cancer tumor types (melanoma and colorectal cancer) compared to OX40 agonist antibody treatment. Heat also reported that ComPACT enhanced antigen-specific T cell infiltration into tumors, improved memory T cell responses and demonstrated greater specificity than OX40 agonist antibody treatments. In addition, the findings also showed that the ComPACT platform can be adapted to secrete other costimulatory molecules, including TL1A, 4-1BBL and ICOSL.
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"We are pleased to have our work published in ‘Cancer Immunology Research.’ These data suggest that local vaccine co-stimulation has compelling advantages compared to systemic antibody co-stimulation," said Taylor Schreiber, M.D., Ph.D., Heat’s Chief Scientific Officer. "This combination platform provides flexibility to deliver multiple costimulatory ligands, which appear to outperform agonist antibodies in terms of immune response and tumor rejection, warranting further study in human clinical trials."