On April 15, 2016 Kite Pharma, Inc., (Nasdaq:KITE) ("Kite") a clinical-stage biopharmaceutical company focused on developing engineered autologous T cell therapy (eACT) products for the treatment of cancer, reported the schedule of presentations and addresses related to its engineered cell therapy programs at the upcoming AACR (Free AACR Whitepaper) Annual Meeting in New Orleans, Louisiana (Press release, Kite Pharma, APR 15, 2016, View Source [SID:1234510955]). Topics will include KTE-C19, Kite’s lead chimeric antigen receptor (CAR) product candidate, as well as engineered T cell receptor (TCR) product candidates targeting solid tumors that express the MAGE-A3 and KRAS cancer proteins. KTE-C19 is currently being studied in four pivotal clinical trials. Clinical study of the MAGE-A3 TCR and pre-clinical study of KRAS TCRs are being advanced as part of a Cooperative Research and Development Agreement (CRADA) between Kite and the National Cancer Institute.

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Oral Presentations

Updated Phase 1 Results from ZUMA-1: A Phase 1-2 Multi-Center Study Evaluating the Safety and Efficacy of KTE-C19 (Anti-CD19 CAR T Cells) in Subjects with Refractory Aggressive Non-Hodgkin Lymphoma (NHL)
Date: April 19, 2016, 4:00 – 4:15PM Central Time
Session: Early Clinical Trials Evaluating Cell-based, Checkpoint Inhibitors, and Novel Immunotherapeutics
Abstract Number: CT135
Location: Room 343, Morial Convention Center
Presenter: Armin Ghobadi, M.D., Washington University, St. Louis, MO

A Phase 1 Study of an HLA-DPB1*0401-restricted T Cell Receptor Targeting MAGE-A3 for Patients with Metastatic Cancer
Date: April 17, 2016, 3:15 – 3:35PM Central Time
Session: Immuno-Oncology Clinical Trials I
Abstract Number: CT003
Location: La Nouvelle Orleans Ballroom, Morial Convention Center
Presenter: Yong-Chen W. Lu, Ph.D., Surgery Branch, National Cancer Institute

Session Presentations

Plenary Session: T Cell Recognition of Human Cancer
Date: April 17, 2016, 11:00 – 11:30AM Central Time
Session: PL01 Opening Plenary – Breakthroughs in Cancer Research: Genomics, Epigenetics, and Immunomodulation
Location: Hall F, Morial Convention Center
Speaker: Ton Schumacher, Ph.D., Netherlands Cancer Institute

Targeting Cancers with Engineered T Cells or BiTES: Towards Broader Application
Date: April 18, 2016, 5:00 – 6:30PM Central Time
Session: Forum FO09
Location: La Nouvelle Orleans Ballroom, Morial Convention Center
Invited Speaker: David Chang, M.D., Ph.D., Kite Pharma

Poster Presentations

Manufacturing and Characterization of KTE-C19 in a Multicenter Trial of Subjects with Refractory Aggressive Non-Hodgkin’s Lymphoma (NHL) (ZUMA-1)
Date: April 18, 2016, 1:00 – 5:00PM Central Time
Session: Adoptive Cell Therapy
Abstract Number: 2308
Location: Poster Hall, Section 25, Poster Board 20
Presenter: John M. Rossi, Kite Pharma

Comparative Evaluation of Peripheral Blood T Cells and Resultant Engineered Anti-CD19 CAR T Cell Products from Relapsed/Refractory Non-Hodgkin’s Lymphoma (NHL) Patients
Date: April 18, 2016, 1:00 – 5:00PM Central Time
Session: Adoptive Cell Therapy
Abstract Number: 2305
Location: Poster Hall, Section 25, Poster Board 17
Presenter: Timothy J. Langer, Kite Pharma

Identification of T-cell Receptors Targeting KRAS-mutated Human Tumors
Date: April 19, 2016, 8:00AM – 12:00PM Central Time
Session: Late-Breaking Research: Experimental and Molecular Therapeutics 3
Abstract Number: LB-242
Location: Poster Hall, Section 11, Poster Board 22
Presenters: James C. Yang, M.D., National Cancer Institute, National Institutes of Health