On June 29, 2015 Epizyme reported that updated data from the phase 1 portion of its ongoing phase 1/2 study of tazemetostat will be presented during the European Cancer Congress 2015, hosted by the European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper), to be held in Vienna, Austria, September 25-28, 2015 (Press release, Epizyme, JUN 29, 2015, View Source [SID:1234506010]). Tazemetostat is a first-in-class EZH2 inhibitor that Epizyme is currently studying in patients with relapsed or refractory B-cell non-Hodgkin lymphomas (NHL) and advanced solid tumors, including INI1-deficient tumors.
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A Phase 1 Study of EPZ-6438 (E7438), an Enhancer of Zeste-Homolog 2 (EZH2)
Inhibitor: Preliminary Activity in INI1-negative Tumors
Speaker: Antonine Italiano, M.D., Ph.D., Institut Bergonié, Bourdeaux, France
Session Title: Proffered Paper Session: Early Drug Development (Hall C1)
Session Date/Time: Saturday, September 26, 10:30 a.m. -12:30 p.m. CET
About EZH2 in Cancer
EZH2 is a histone methyltransferase (HMT) that is increasingly understood to play a potentially oncogenic role in a number of cancers. These include non-Hodgkin lymphomas, INI1-deficient cancers such as malignant rhabdoid tumors, epithelioid sarcomas and synovial sarcoma; and a range of other solid tumors.
About Tazemetostat
Epizyme is developing tazemetostat for the treatment of non-Hodgkin lymphoma patients and patients with INI1-deficient solid tumors. Tazemetostat is a first-in-class small molecule inhibitor of EZH2 created by Epizyme using its proprietary product platform. In some human cancers, aberrant EZH2 enzyme activity results in misregulation of genes that control cell proliferation resulting in the rapid and unconstrained growth of tumor cells. Tazemetostat is the WHO International Non-Proprietary Name (INN) for compound EPZ-6438.
Tazemetostat is the second HMT inhibitor to enter human clinical development (following Epizyme’s DOT1L inhibitor, pinometostat, also known as EPZ-5676).
Additional information about this program, including clinical trial information, may be found here: View Source