On January 19, 2011 Theraclone Sciences reported that they have entered into a multi-year research and development collaboration with Pfizer (Press release Theraclone Sciences, JAN 19, 2011, View Source [SID:1234500951]). The collaboration will use Theraclone’s I-STAR technology to discover broadly protective monoclonal antibodies against up to four undisclosed targets in the areas of infectious disease and cancer. I-STAR technology is used to screen and identify novel human antibodies to pathogenic agents and endogenous therapeutic targets and is unique in its ability to rapidly test the function of tens of thousands of natural human antibodies and find those with exceptional biologic activity.
Under the terms of the agreement, Theraclone and Pfizer will embark on a discovery program to identify broadly reactive antibodies directed against up to two infectious disease targets and up to two cancer targets. Pfizer will receive an exclusive worldwide license to any therapeutic antibodies discovered under the collaboration. Theraclone is eligible to receive undisclosed royalties on sales of any developed products and up to $632 million in research funding and milestone payments upon the achievement of discovery, development, regulatory and commercialization milestones. Pfizer will be responsible for preclinical and clinical development of the antibodies.

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